1005402-63-0Relevant articles and documents
Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity
Hudkins, Robert L.,Aimone, Lisa D.,Bailey, Thomas R.,Bendesky, Robert J.,Dandu, Reddeppa Reddy,Dunn, Derek,Gruner, John A.,Josef, Kurt A.,Lin, Yin-Guo,Lyons, Jacquelyn,Marcy, Val R.,Mathiasen, Joanne R.,Sundar, Babu G.,Tao, Ming,Zulli, Allison L.,Raddatz, Rita,Bacon, Edward R.
scheme or table, p. 5493 - 5497 (2011/10/12)
H3R structure-activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules wi