Isoxazolopyrimidines as novel F508-CFTR correctors
Using a cell-based high-throughput screen, we identified isoxazolo[5,4-d]pyrimidines as novel small-molecule correctors of the cystic fibrosis mutant protein F508-CFTR. 22 Isoxazolo[5,4-d]pyrimidine analogues were synthesized and tested. Synthesis of the
Yu, Gui Jun,Yang, Baoxue,Verkman,Kurth, Mark J.
experimental part
p. 1063 - 1066
(2010/07/03)
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