Mechanochemical ritter reaction: A rapid approach to functionalized amides at room temperature
A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using a Br?nsted acid catalyst. Its general application has been verified through a substrate screening comprising a wide range of functionalized nitriles as well as secondary and tertiary alcohols. Gentle Ritter: A fast and efficient mechanochemical Ritter reaction under mild conditions is described. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using sulfuric acid as catalyst.
Dokli, Irena,Gredi?ak, Matija
supporting information
p. 2727 - 2732
(2015/04/27)
Polyvinylpolypyrrolidone-supported boron trifluoride; Highly efficient catalyst for the synthesis of N-tert-butyl amides
Highly efficient method for the preparation of N-tert-butyl amides by reaction of nitriles with tert-butyl acetate is described using polyvinylpolypyrrolidone-supported boron trifluoride (PVPP-BF3) at 70 °C in good to excellent yields. Selective amidation of benzonitrile in the presence of acetonitrile was also achieved. polyvinylpolypyrrolidone-boron trifluoride complex shows non-corrosive and stable solid catalyst elevated Lewis acid property.
Mokhtary, Masoud,Najafizadeh, Faranak
experimental part
p. 576 - 582
(2012/06/30)
NEW 2,3,4,5-TERAHYDRO-1H-PYRIDO[ 4,3-B] INDOLE COMPOUNDS AND METHODS OF USE THEREOF
This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5- tetrahydro-lH-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the
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Page/Page column 171
(2009/09/05)
Rare earth exchanged HY zeolite, an efficient catalyst for the synthesis of N-monosubstituted amides
The use of rare earth exchanged HY (RE HY) zeolite catalyst for the synthesis of N-monosubstituted amides 3a-g starting from alcohols 1 and nitriles 2 in good yields is described
Deshmukh, A. R. A. S.,Gumaste, V. K.,Bhawal, B. M.
p. 369 - 371
(2007/10/03)
Acyloxylation at the 4-Position of Azetidin-2-ones
The copper-catalysed reaction of azetidin-2-ones with t-butyl perbenzoate or peracetate affords the corresponding 4-benzoyloxy- and acetoxy-substituted β-lactams, respectively.N-Unsubstituted 4-acyloxyazetidinones can be synthesized by dearylation of the N-(4-methoxyphenyl)-substituted products with ceric ammonium nitrate.Acyloxylation of β-lactams that are monosubstituted at C-3 affords predominantly trans-products.
Easton, Christopher J.,Love, Stephen G.,Wang, Peng
p. 277 - 282
(2007/10/02)
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