100859-81-2

Usage

Uses

Used in Pharmaceutical Synthesis:
N-(tert-butyl)-3-chloropropanamide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of bioactive compounds.
Used in Agrochemical Production:
N-(tert-butyl)-3-chloropropanamide is also utilized in the production of agrochemicals, serving as a crucial component in the synthesis of various agricultural products.
Used in Organic Synthesis as a Chiral Building Block:
Due to its stereocenter at the amide nitrogen, N-(tert-butyl)-3-chloropropanamide is used as a chiral building block in organic synthesis, playing a significant role in the creation of enantioselective reactions and the production of enantiomerically pure compounds.

InChI:InChI=1/C7H14ClNO/c1-7(2,3)9-6(10)4-5-8/h4-5H2,1-3H3,(H,9,10)

Upstream product

• 802294-64-0 propionic acid 
• 75-64-9 tert-butylamine 
• 542-76-7 3-Chloropropionitrile 
• 540-88-5 acetic acid tert-butyl ester 
• 75-65-0 tert-butyl alcohol 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 106576-05-0 4-benzoyloxy-1-t-butylazetidin-2-one 

Relevant academic research and scientific papers

Mechanochemical ritter reaction: A rapid approach to functionalized amides at room temperature

A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using a Br?nsted acid catalyst. Its general application has been verified through a substrate screening comprising a wide range of functionalized nitriles as well as secondary and tertiary alcohols. Gentle Ritter: A fast and efficient mechanochemical Ritter reaction under mild conditions is described. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using sulfuric acid as catalyst.

Polyvinylpolypyrrolidone-supported boron trifluoride; Highly efficient catalyst for the synthesis of N-tert-butyl amides

Highly efficient method for the preparation of N-tert-butyl amides by reaction of nitriles with tert-butyl acetate is described using polyvinylpolypyrrolidone-supported boron trifluoride (PVPP-BF3) at 70 °C in good to excellent yields. Selective amidation of benzonitrile in the presence of acetonitrile was also achieved. polyvinylpolypyrrolidone-boron trifluoride complex shows non-corrosive and stable solid catalyst elevated Lewis acid property.

NEW 2,3,4,5-TERAHYDRO-1H-PYRIDO[ 4,3-B] INDOLE COMPOUNDS AND METHODS OF USE THEREOF

This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5- tetrahydro-lH-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the

Rare earth exchanged HY zeolite, an efficient catalyst for the synthesis of N-monosubstituted amides

The use of rare earth exchanged HY (RE HY) zeolite catalyst for the synthesis of N-monosubstituted amides 3a-g starting from alcohols 1 and nitriles 2 in good yields is described

Acyloxylation at the 4-Position of Azetidin-2-ones

The copper-catalysed reaction of azetidin-2-ones with t-butyl perbenzoate or peracetate affords the corresponding 4-benzoyloxy- and acetoxy-substituted β-lactams, respectively.N-Unsubstituted 4-acyloxyazetidinones can be synthesized by dearylation of the N-(4-methoxyphenyl)-substituted products with ceric ammonium nitrate.Acyloxylation of β-lactams that are monosubstituted at C-3 affords predominantly trans-products.