100859-81-2

Basic information

• Product Name: N-(tert-butyl)-3-chloropropanamide
• Synonyms: N-(tert-butyl)-3-chloropropanamide;UKRORGSYN-BB BBV-026826;propanamide, 3-chloro-N-(1,1-dimethylethyl)-;N-(tert-butyl)-3-chloropropanamide(SALTDATA: FREE)
• CAS NO: 100859-81-2
• Molecular Formula: C₇H₁₄ClNO
• Molecular Weight: 163.65
• Mol File: 100859-81-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 277.7°C at 760 mmHg
• Flash Point: 121.8°C
• Appearance: /
• Density: 1.013g/cm³
• Vapor Pressure: 0.00445mmHg at 25°C
• Refractive Index: 1.444
• CAS DataBase Reference: N-(tert-butyl)-3-chloropropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyl)-3-chloropropanamide(100859-81-2)
• EPA Substance Registry System: N-(tert-butyl)-3-chloropropanamide(100859-81-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 100859-81-2(Hazardous Substances Data)

Usage

General Description

N-(tert-butyl)-3-chloropropanamide is a chemical compound with the molecular formula C7H15ClNO. It is an amide derivative of 3-chloropropanoic acid and is commonly used in the synthesis of various pharmaceuticals and agrochemicals. N-(tert-butyl)-3-chloropropanamide is a white to light yellow crystalline solid that is insoluble in water but soluble in organic solvents. N-(tert-butyl)-3-chloropropanamide is also known for its potential as a chiral building block in organic synthesis due to its stereocenter at the amide nitrogen, making it a valuable intermediate in the production of bioactive compounds. Additionally, it is important to handle this chemical with care, as it may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H14ClNO/c1-7(2,3)9-6(10)4-5-8/h4-5H2,1-3H3,(H,9,10)

Upstream product

• 542-76-7 3-Chloropropionitrile 
• 75-65-0 tert-butyl alcohol 
• 540-88-5 acetic acid tert-butyl ester 
• 802294-64-0 propionic acid 
• 75-64-9 tert-butylamine 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 106576-05-0 4-benzoyloxy-1-t-butylazetidin-2-one 

Relevant articles and documents

Mechanochemical ritter reaction: A rapid approach to functionalized amides at room temperature

A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using a Br?nsted acid catalyst. Its general application has been verified through a substrate screening comprising a wide range of functionalized nitriles as well as secondary and tertiary alcohols. Gentle Ritter: A fast and efficient mechanochemical Ritter reaction under mild conditions is described. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using sulfuric acid as catalyst.

NEW 2,3,4,5-TERAHYDRO-1H-PYRIDO[ 4,3-B] INDOLE COMPOUNDS AND METHODS OF USE THEREOF

This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5- tetrahydro-lH-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the

Acyloxylation at the 4-Position of Azetidin-2-ones

The copper-catalysed reaction of azetidin-2-ones with t-butyl perbenzoate or peracetate affords the corresponding 4-benzoyloxy- and acetoxy-substituted β-lactams, respectively.N-Unsubstituted 4-acyloxyazetidinones can be synthesized by dearylation of the N-(4-methoxyphenyl)-substituted products with ceric ammonium nitrate.Acyloxylation of β-lactams that are monosubstituted at C-3 affords predominantly trans-products.