100866-13-5

Basic information

• Product Name: 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE
• Synonyms: 2-Pyridin-4-yl-1-p-polyl-ethanone;Ethanone, 1-(4-Methylphenyl)-2-(4-pyridinyl)-;1-(4-Methylphenyl)-2-(4-pyridinyl)-ethanone;2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE
• CAS NO: 100866-13-5
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• Mol File: 100866-13-5.mol

Chemical Properties

• Melting Point: 110-111 °C(Solv: ethyl acetate (141-78-6); isopropyl ether (108-20-3))
• Boiling Point: 185.4 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: /
• Density: 1.105 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 5.22±0.10(Predicted)
• CAS DataBase Reference: 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE(100866-13-5)
• EPA Substance Registry System: 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE(100866-13-5)

Safety Data

• Hazardous Substances Data: 100866-13-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the development of new drugs with potential therapeutic applications. 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE's versatility in chemical reactions enables the creation of a wide range of pharmaceutical agents.
Used in Agrochemical Industry:
In the agrochemical industry, 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE serves as a building block for the production of various agrochemicals. Its structural properties make it suitable for the synthesis of compounds with potential applications in crop protection, pest control, and other agricultural areas. 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE's ability to be modified and combined with other chemical entities contributes to the development of innovative agrochemical products.
Used as a Building Block in Organic Synthesis:
2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE is used as a building block in the production of other organic compounds. Its unique structure and reactivity make it a valuable component in the synthesis of a variety of organic molecules. 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE's ability to participate in various chemical reactions allows for the creation of diverse organic compounds with different applications in various industries.
Safety Precautions:
It is important to handle 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE with care and follow the necessary safety protocols while working with it. Due to its potential applications in the pharmaceutical and agricultural industries, proper handling and storage are essential to ensure the safety of both the environment and the individuals involved in its production and use.

Upstream product

• 110531-58-3 2-[1-(2,6-dichloro-benzyl)-1H-[4]pyridylidene]-1-p-tolyl-ethanone 
• 108-89-4 picoline 
• 104-85-8 para-methylbenzonitrile 
• 21384-44-1 1-(4-methylbenzoyl)-2-methylaziridine 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 40774-05-8 1-(2,6-dichloro-benzyl)-pyridinium; bromide 
• 122-00-9 para-methylacetophenone 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 224038-61-3 [4-(4-methylphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine 

Relevant articles and documents

Continuous-Flow Synthesis of 2 H -Azirines and Their Diastereoselective Transformation to Aziridines

Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2-subst

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Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists

To investigate the potency of an adenosine A3 receptor (A 3AR) antagonist as an anti-asthmatic drug, a novel series of 4-phenyl-5-pyridyl-1,3-thiazole derivatives was synthesized and evaluated in human adenosine A1, A

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors

A novel series of 4-phenyl-5-pyridyl-1,3-thiazole analogues possessing potent in vitro inhibitory activity against p38 mitogen-activated protein kinase and the release of tumor necrosis factor-α (TNF-α) from human monocytic THP-1 cells stimulated by lipopolysaccharide has been identified. Subsequent structure-activity relationship (SAR) studies and optimization for absorption, distribution, metabolism, and elimination (ADME) profiles led to the identification of compounds 7g and 10b as orally active lead candidates that block the in vivo production of proinflammatory cytokine (TNF-α). In pharmacokinetic studies, compound 10b showed good oral administration in mice and demonstrated significant in vivo anti-inflammatory activity in an anti-collagen monoclonal antibody-induced arthritis mouse model (minimum effective dose (MED)=30 mg/kg). Further elucidation of this class of compounds may provide novel anti-inflammatory agents, such as anti-rheumatoid arthritis drugs.

Adenosine A3 receptor antagonists

A pharmaceutical composition for antagonizing adenosine at adenosine A3receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.

Rate-equilibrium relationships for the deprotonation of 4-phenacylpyridines and 4-phenacylpyridinium cations

Substituent effects upon the equilibria and kinetics of enolate ion formation from eight 4-(X-phenacyl)pyridines (5), eight 1-methyl-4-(X-phenacyl)pyridinium cations (6), five 1-benzyl-4-(X-phenacyl)pyridinium cations (7), and eight 1-(X-benzyl)-4-phenacy