- Organic light-emitting compound and organic electroluminescent device
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The invention provides an organic light-emitting compound as shown in a formula I. The invention also provides an application of the organic light-emitting compound in an electroluminescent device. According to the organic light-emitting compound provided
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Paragraph 0125-0126
(2021/07/24)
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- Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors
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Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) has been identified as a potential target for the development of novel drugs against multi-drug resistant malaria. A series of benzofuran-based compounds was synthesised and evaluated as inhibitors of recombinantly expressed and purified PfGSK-3 and human glycogen synthase kinase-3 beta (HsGSK-3β). Of this series, five compounds (5k, 5m, 5p, 5r, 5s) preferentially inhibited PfGSK-3, with four of these compounds exhibiting IC50 values in the sub-micromolar range (0.00048–0.440 μM). Evaluation of the structure-activity relationships required for PfGSK-3 selective inhibition indicated that a C6-OCH3 substitution on ring A is preferred, while the effect of the ring B substituent on activity, in decreasing order is: C4′-CN > C4′-F > C3′-OCH3 > C3′,4′-diCl. To date, development of PfGSK-3 inhibitors has been limited to the 4-phenylthieno[2,3-b]pyridine class. Chalcone-based scaffolds, such as the benzofurans described herein, are promising new hits which can be explored for future design of PfGSK-3 selective inhibitors.
- Moolman, Chantalle,van der Sluis, Rencia,Beteck, Richard M.,Legoabe, Lesetja J.
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- Synthesis method of benzofuran compound
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The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, a
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Paragraph 0053-0060; 0062; 0063
(2021/05/19)
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- Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies
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Thirty benzofuran-2-yl(phenyl)methanones 1–30 were synthesized and characterized their structures by spectroscopic techniques. Substituted phenacyl bromide and different derivatives of 2-hydroxy-benzaldehyde treated in the presence of anhydrous K2/s
- Ali, Basharat,Ali, Irfan,Chigurupati, Sridevi,Iqbal, Muhammad Shahid,Ji, Xingyue,Khan, Khalid Mohammed,Perveen, Shahnaz,Rafique, Rafaila,Rehman, Ashfaq Ur,Salar, Uzma,Taha, Muhammad,Wadood, Abdul
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- Synthesis and anticandidal activities of some aryl (5-chloro-benzofuran-2-yl) ketoximes
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Background: In this study, some aryl (5-chloro-benzofuran-2-yl) ketoximes and their ethers were synthesised to evaluate their antifungal activity against C. albicans, C. glabrata, C. krusei, and C. parapsilosis. Methods: The structure elucidation of the c
- Karaburun, Ahmet Cagri
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p. 427 - 436
(2019/06/18)
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- Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy
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A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.
- Xuan, Qingqing,Kong, Weiguang,Song, Qiuling
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p. 7602 - 7607
(2017/07/26)
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- Palladium-catalyzed paraformaldehyde insertion: A three-component synthesis of benzofurans
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An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.
- Cheng, Xiufang,Peng, Yi,Wu, Jun,Deng, Guo-Jun
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supporting information
p. 2819 - 2823
(2016/03/12)
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- Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives
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A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.
- Xu, Wengang,Li, Qingcui,Cao, Chuanpeng,Zhang, Fanglin,Zheng, Hua
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p. 6158 - 6161
(2015/06/08)
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- DABCO-promoted efficient and convenient synthesis of benzofurans
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An efficient and convenient synthesis of benzofurans has been described from phenacyl halides and o-hydroxy benzaldehyde in the presence of DABCO. The procedure is applicable for a variety of phenacyl halides and provide a variety of benzofurans. DABCO ac
- Meshram,Reddy, B. Chennakesava,Prasad,Goud, P. Ramesh,Kumar, G. Santosh,Kumar, R. Naveen
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experimental part
p. 1669 - 1676
(2012/05/04)
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- ALLOSTERIC PROTEIN KINASE MODULATORS
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The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
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Page/Page column 71
(2012/03/10)
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- DMAP-catalyzed cascade reaction: One-pot synthesis of benzofurans in water
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A series of benzofurans were efficiently synthesized in good to excellent yields using 4-dimethylaminopyridine (DMAP) catalyzed cascade reaction between salicylaldehydes and halogenated ketones in water at 80 °C opened atmosphere.
- Shang, Yongjia,Wang, Cuie,He, Xinwei,Ju, Kai,Zhang, Min,Yu, Shuyan,Wu, Jiaping
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experimental part
p. 9629 - 9633
(2011/01/03)
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- 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds
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The modulation of protein kinase activities by low molecular weight compounds is a major goal of current pharmaceutical developments. In this line, important efforts are directed to the development of drugs targeting the conserved ATP binding site. Howeve
- Stroba, Adriana,Schaeffer, Francis,Hindie, Valerie,Lopez-Garcia, Laura,Adrian, Iris,Fr?hner, Wolfgang,Hartmann, Rolf W.,Biondi, Ricardo M.,Engel, Matthias
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supporting information; experimental part
p. 4683 - 4693
(2010/02/28)
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- Microwave-mediated solvent free Rap-Stoermer reaction for efficient synthesis of benzofurans
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The Rap-Stoermer reaction of salicylaldehydes with diverse phenacyl bromide and phenacyl iodides proceeded cleanly to afford various functionalized benzofurans in excellent yields under base-mediated solvent free microwave irradiation conditions.
- Rao, Maddali L.N.,Awasthi, Dheeraj K.,Banerjee, Debasis
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p. 431 - 434
(2008/02/03)
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- Solid state synthesis of 2-aroylbenzo[b]furans, 1,3-thiazoles and 3-aryl-5,6-dihydroimidazo[2,1-b][1,3]thiazoles from α-tosyloxyketones using microwave irradiation
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The expeditious solventless syntheses of 2-aroylbenzo[e]furans, 1,3-thiazoles and 3-aryl-5,6-dihydroimidazo[2,1-b]-[1,3]thiazoles are described from readily accessible α-tosyloxyketones and mineral oxides in processes that are accelerated by exposure to m
- Varma, Rajender S.,Kumar, Dalip,Liesen, Per J.
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p. 4093 - 4096
(2007/10/03)
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