100914-68-9

Upstream product

• 70-11-1 α-bromoacetophenone 
• 635-93-8 5-chlorosalicyclaldehyde 
• 4636-16-2 iodoacetophenone 
• 118110-23-9 (E)-3-(5-chloro-2-hydroxyphenyl)-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 
• 23145-05-3 5-chlorobenzofuran 
• 553-54-8 lithium benzoate 
• 50-00-0 formaldehyd 
• 695-96-5 2-bromo-4-chlorophenol 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 1927-94-2 3-chlorosalicylaldehyde 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1638610-60-2 methyl 2-(2-benzoyl-5-chlorobenzofuran-3-yl)butanoate 
• 1638610-57-7 C₂₀H₁₇ClO₄ 
• 1638610-56-6 methyl 2-(2-benzoyl-5-chlorobenzofuran-3-yl)propanoate 
• 1663511-55-4 methyl 3-(2-benzoyl-5-chlorobenzofuran-3-yl)propanoate 
• 1638610-58-8 ethyl 2-(2-benzoyl-5-chlorobenzofuran-3-yl)propanoate 
• 1663511-56-5 ethyl 3-(2-benzoyl-5-chlorobenzofuran-3-yl)propanoate 
• 99661-10-6 benzoyl-2 bromo-3 chloro-5 benzofuranne 
• 1221963-53-6 ethyl (Z)-3-(5-chlorobenzofuran-2-yl)-3-phenylacrylate 
• 1221963-54-7 ethyl (E)-3-(5-chlorobenzofuran-2-yl)-3-phenylacrylate 

Relevant academic research and scientific papers

Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors

Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) has been identified as a potential target for the development of novel drugs against multi-drug resistant malaria. A series of benzofuran-based compounds was synthesised and evaluated as inhibitors of recombinantly expressed and purified PfGSK-3 and human glycogen synthase kinase-3 beta (HsGSK-3β). Of this series, five compounds (5k, 5m, 5p, 5r, 5s) preferentially inhibited PfGSK-3, with four of these compounds exhibiting IC50 values in the sub-micromolar range (0.00048–0.440 μM). Evaluation of the structure-activity relationships required for PfGSK-3 selective inhibition indicated that a C6-OCH3 substitution on ring A is preferred, while the effect of the ring B substituent on activity, in decreasing order is: C4′-CN > C4′-F > C3′-OCH3 > C3′,4′-diCl. To date, development of PfGSK-3 inhibitors has been limited to the 4-phenylthieno[2,3-b]pyridine class. Chalcone-based scaffolds, such as the benzofurans described herein, are promising new hits which can be explored for future design of PfGSK-3 selective inhibitors.

Organic light-emitting compound and organic electroluminescent device

The invention provides an organic light-emitting compound as shown in a formula I. The invention also provides an application of the organic light-emitting compound in an electroluminescent device. According to the organic light-emitting compound provided

Synthesis method of benzofuran compound

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, a

Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies

Thirty benzofuran-2-yl(phenyl)methanones 1–30 were synthesized and characterized their structures by spectroscopic techniques. Substituted phenacyl bromide and different derivatives of 2-hydroxy-benzaldehyde treated in the presence of anhydrous K2/s

Synthesis and anticandidal activities of some aryl (5-chloro-benzofuran-2-yl) ketoximes

Background: In this study, some aryl (5-chloro-benzofuran-2-yl) ketoximes and their ethers were synthesised to evaluate their antifungal activity against C. albicans, C. glabrata, C. krusei, and C. parapsilosis. Methods: The structure elucidation of the c

Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy

A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.

Palladium-catalyzed paraformaldehyde insertion: A three-component synthesis of benzofurans

An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

DABCO-promoted efficient and convenient synthesis of benzofurans

An efficient and convenient synthesis of benzofurans has been described from phenacyl halides and o-hydroxy benzaldehyde in the presence of DABCO. The procedure is applicable for a variety of phenacyl halides and provide a variety of benzofurans. DABCO ac