1009227-82-0 Usage
General Description
2-[[2-Fluorophenyl)sulfonyl]amino]-3-phenylpropanoic acid, also known as celecoxib, is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis. It works by inhibiting the production of certain chemicals in the body that cause inflammation and pain. Celecoxib is a specific inhibitor of the enzyme cyclooxygenase-2 (COX-2), which is involved in the production of prostaglandins, a group of lipid compounds that cause inflammation, fever, and pain. By blocking COX-2, celecoxib reduces the production of prostaglandins, leading to decreased inflammation and pain. However, the use of celecoxib is associated with potential side effects, including an increased risk of heart attacks and strokes, as well as gastrointestinal bleeding. Therefore, it should be used with caution and under the guidance of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 1009227-82-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,9,2,2 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1009227-82:
(9*1)+(8*0)+(7*0)+(6*9)+(5*2)+(4*2)+(3*7)+(2*8)+(1*2)=120
120 % 10 = 0
So 1009227-82-0 is a valid CAS Registry Number.
1009227-82-0Relevant articles and documents
MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF
-
, (2012/08/07)
The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula (I) compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.
Small-molecule inhibitors of the TLR3/dsRNA complex
Cheng, Kui,Wang, Xiaohui,Yin, Hang
, p. 3764 - 3767 (2011/06/18)
The protein-RNA interface has been regarded as "undruggable" despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-molecule probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.
