100935-99-7 Usage
Uses
Used in Pharmaceutical Industry:
Ent Naxagolide Hydrochloride is used as an antiparkinsonian drug for the treatment of extrapyramidal disorders. It functions by acting as a dopamine D2-receptor agonist, which helps alleviate the symptoms associated with these conditions.
Used in Neurological Treatment:
Ent Naxagolide Hydrochloride is used as a therapeutic agent for neurological disorders, specifically targeting the treatment of extrapyramidal disorders. Its agonist properties on dopamine D2-receptors contribute to its effectiveness in managing the symptoms of Parkinson's disease and other related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 100935-99-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,3 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 100935-99:
(8*1)+(7*0)+(6*0)+(5*9)+(4*3)+(3*5)+(2*9)+(1*9)=107
107 % 10 = 7
So 100935-99-7 is a valid CAS Registry Number.
100935-99-7Relevant articles and documents
Synthesis and pharmacological activity of the hexahydro-4H-naphth[1,2b][1,4]-oxazines: A new series of potent dopamine receptor agonists
Dykstra,Hazelhoff,Mulder,et al.
, p. 247 - 250 (2007/10/02)
The synthesis in 8 steps of a new series of potent dopamine (DA) agonists, the trans-hexahydro-4H-naphth[1,2b][1,4]oxazines, is described. The yields of all steps are good to excellent. The dopaminergic activity of these new compounds was evaluated in rats in three test systems, i.e. for the ability to displace the specific in vitro binding of [3H]-DPAT to rat brain striatal homogenates for the effects on DA metabolism in the corpus striatum and for their ability to induce stereotypy. The activity of trans-N-n-propyl-9-hydroxy-2,3,4a,5,6,10b-hexahydro-4H-naphth[1,2b][1,4] oxazine (N-0500) was found to be comparable to that of the known potent DA agonist RU 29717.
