- Synthese et activite biologique de prodrogues de l'acide oxolinique
-
Synthesis and biological activities of oxolinic acid pro-drugs.Antiseptic phenols, anti-inflammatory acids and polyethyleneglycol moieties have been attached by labile bonds to oxolinic acid giving pro-drugs with anti-bacterial activities.Some of them are more soluble in water, exhibit a more sustained action in the time and give higher plasma and tissue concentrations compared with the free drug.
- Loubinoux, B,Colin, JL,Thomas, V
-
p. 461 - 467
(2007/10/02)
-
- Sulfonic and Phosphonic Acids Formed by Bisulfite and Phosphite Adduct Formation with Pyrimidinones
-
By analogy with carbonyl compounds, ?-electron deficient 2-pyrimidinones form adducts with sodium bisulfite and phosphite esters.Both the 3,4- and 3,6-bisulfite adducts were found.The 3,4-isomer was often predominant and was obtained isomerically pure by selective precipitation from an aqueous solution.The adduct formation is reversible in aqueous solution.The adduct was also readily cleaved by trifluoroacetic acid.With tris(trimethylsilyl) phosphite, regiospecific formation of the 3,4-adduct was observed.The corresponding 3,4-dihydro-4-phosphonic acid was prepared by methanol cleavage of the silyl ester function.
- Benneche, Tore,Strande, Per,Undheim, Kjell
-
p. 448 - 454
(2007/10/02)
-