- COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF
-
Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
- -
-
Page/Page column 138
(2010/11/03)
-
- OXAZOLES AS MODULATORS OF CHEMOKINE RECEPTORS
-
The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof; wherein R1-R7, X, Y, m, and n are as described herein. Compounds of the present invention are useful for the treatment of a variety of diseases associated with overexpression of the CCR2 receptor.
- -
-
Page/Page column 23-24
(2010/08/04)
-
- ANALGESIC N-PHENYL-N-(3-OR 1-3-ME-4-PIPERIDINYL)AMIDES
-
N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): STR1 wherein X, Ar, R and R 1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
- -
-
-