34737-89-8

Basic information

• Product Name: 1-BENZYL-3-METHYL-4-PIPERIDONE
• Synonyms: TIMTEC-BB SBB001741;4-PIPERIDINONE, 3-METHYL-1-(PHENYLMETHYL)-;1-BENZYL-3-METHYL-4-PIPERIDONE;1-BENZYL-3-METHYLPIPERIDIN-4-ONE;N-BeNzyl-3-methyl-4-piperidoNe;3-Methyl-1-(phenylmethyl)-4-piperidinone;1-Benzyl-3-methyl-4-piperidone,99%;1-Benzyl-3-methyl-4-piperidinone
• CAS NO: 34737-89-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28
• EINECS: 252-176-5
• Product Categories: pharmacetical;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 34737-89-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 99°C/0.05mmHg(lit.)
• Flash Point: 134.9°C
• Appearance: Clear slightly yellow to yellow/Liquid
• Density: 1.0156 (rough estimate)
• Vapor Pressure: 0.498mmHg at 25°C
• Refractive Index: 1.5315-1.5335
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Methanol
• PKA: 7.11±0.40(Predicted)
• CAS DataBase Reference: 1-BENZYL-3-METHYL-4-PIPERIDONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3-METHYL-4-PIPERIDONE(34737-89-8)
• EPA Substance Registry System: 1-BENZYL-3-METHYL-4-PIPERIDONE(34737-89-8)

Safety Data

• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 45-36/37/39-26
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 34737-89-8(Hazardous Substances Data)

Usage

Chemical Properties

clear slightly yellow to yellow liquid

Uses

1-Benzyl-3-methyl-4-piperidone is a piperidine derivative used in the preparation of Fentanyl (F274990) analogs with analgesic activity.

InChI:InChI=1/C5H4N2O/c8-4-5-3-6-1-2-7-5/h1-4H

Upstream product

• 127956-04-1 ethyl 1-benzyl-3-methyl-4-oxopiperidine-3-carboxylate 
• 41276-30-6 C₉H₁₄O₃NC₆H₅ 
• 1589566-76-6 2-methyl-3-[(2-iodoethyl)(phenylmethyl)amino]-propanoic acid 
• 1285576-65-9 C₁₄H₂₁NO₃ 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 74-88-4 methyl iodide 
• 7006-50-0 1-benzyl-N-methylpiperidin-4-amine 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 103-80-0 phenylacetyl chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 23504-23-6 1-benzyl-3-methyl-4-pyrrolidin-1-yl-1,2,3,6-tetrahydro-pyridine 
• 955028-56-5 1-benzyl-3-methyl-1,4-diazepan-5-one 
• 130150-13-9 Furan-2-carboxylic acid {(3S,4R)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-(2-methoxy-phenyl)-amide 
• 101344-84-7 Furan-2-carboxylic acid {(3S,4R)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-(2-fluoro-phenyl)-amide 
• 101344-84-7 Furan-2-carboxylic acid {(3R,4R)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-(2-fluoro-phenyl)-amide 
• 101345-06-6 N-{(3R,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-N-(2-fluoro-phenyl)-2-methoxy-propionamide 
• 130150-01-5 N-{(3S,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-(2-methoxy-phenyl)-propionamide 
• 101344-78-9 cis-1-<2-(4-ethyl-4,5-dihydro-1H-tetrazolyl)ethyl>-3-methyl-4-piperidine 
• 101344-78-9 trans-1-<2-(4-ethyl-4,5-dihydro-1H-tetrazolyl)ethyl>-3-methyl-4-piperidine 
• 130149-97-2 N-{(3S,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-(2-methoxy-phenyl)-acetamide 
• 101345-47-5 Furan-2-carboxylic acid {(3S,4R)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-phenyl-amide 
• 101344-74-5 N-{(3S,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-phenyl-propionamide 
• 101344-74-5 N-{(3R,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-phenyl-propionamide 
• 101344-76-7 N-{(3S,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-phenyl-acetamide 

Relevant articles and documents

INTERMEDIATES FOR OPTICALLY ACTIVE PIPERIDINE DERIVATIVES AND PREPARATION METHODS THEREOF

A preparation method according to the present invention makes it possible to industrially produce large amounts of highly pure optically active tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate in high yield by use of commercially available reagents and solvents. In addition, the use of novel intermediates according to the present invention makes it possible to produce highly pure optically active tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate in high yield.

5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them

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COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF

Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.