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9-(2-fluorobenzyl)-6-(methylamino)-9H-purine, also known as BW-A 78U, is a potent and selective cAMP phosphodiesterase (PDE4) inhibitor with a micromolar (μM) range IC50 value. It is a synthetic compound belonging to the purine family, which plays a crucial role in various biological processes, including signal transduction and energy metabolism.

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  • 101155-02-6 Structure
  • Basic information

    1. Product Name: 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine
    2. Synonyms: 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine;9-[(2-Fluorophenyl)methyl]-N-methyl-9H-purin-6-amine;BW-A-78U
    3. CAS NO:101155-02-6
    4. Molecular Formula: C13H12FN5
    5. Molecular Weight: 257.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 101155-02-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 477.9°Cat760mmHg
    3. Flash Point: 242.8°C
    4. Appearance: /
    5. Density: 1.36g/cm3
    6. Vapor Pressure: 2.69E-09mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine(101155-02-6)
    12. EPA Substance Registry System: 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine(101155-02-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 101155-02-6(Hazardous Substances Data)

101155-02-6 Usage

Uses

Used in Pharmaceutical Industry:
9-(2-fluorobenzyl)-6-(methylamino)-9H-purine is used as a PDE4 inhibitor for its potential therapeutic applications in treating various inflammatory and immune disorders. By inhibiting PDE4, it increases the intracellular levels of cAMP, which in turn modulates the immune response and reduces inflammation.
Used in Research Applications:
9-(2-fluorobenzyl)-6-(methylamino)-9H-purine is used as a research tool for studying the role of PDE4 in various biological processes and disease mechanisms. Its potent and selective inhibition of PDE4 allows researchers to investigate the effects of cAMP modulation on cellular functions and signaling pathways.
Used in Drug Development:
9-(2-fluorobenzyl)-6-(methylamino)-9H-purine serves as a lead compound for the development of new drugs targeting PDE4. Its structure can be further optimized to improve its potency, selectivity, and pharmacokinetic properties, leading to the discovery of more effective and safer PDE4 inhibitors for clinical use.

Check Digit Verification of cas no

The CAS Registry Mumber 101155-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,1,5 and 5 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 101155-02:
(8*1)+(7*0)+(6*1)+(5*1)+(4*5)+(3*5)+(2*0)+(1*2)=56
56 % 10 = 6
So 101155-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H12FN5.ClH/c1-15-12-11-13(17-7-16-12)19(8-18-11)6-9-4-2-3-5-10(9)14;/h2-5,7-8H,6H2,1H3,(H,15,16,17);1H

101155-02-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine

1.2 Other means of identification

Product number -
Other names BW-A 78U

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101155-02-6 SDS

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