FLAMMABLE. POISONOUS GASES MAY BE PRODUCED IN FIRE. Containers may explode in fire. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. Toxic nitrogen oxides may be formed. Vapors are heavier than air and may travel considerable distance to a source of ignition and flash back.
ChEBI: The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent.
Methylamine is an important kind of fatty amines organic chemicals and is used in a variety of industries such as manufacture of dyestuffs, treatment of cellulose, acetate rayon, as fuel additive, rocket propellant, and leather tanning processes. It can be used in the synthesis of the N-methyl-chloroacetamide that is the intermediate of the organic phosphorus insecticide dimethoate and omethoate; synthesis of the intermediate of the monocrotophos, α-chloro acetoacetyl methylamine; synthesis of the intermediates of carbamate pesticide, carbamoyl chloride and methyl isocyanate; as well as the synthesis of other pesticides varieties such as formamidine, amitraz, and tribenuron, etc. In addition, it can also be used in medicine, rubber, dyes, leather industry and photosensitive materials.
A colorless gas or a liquid. Pungent fishy odor resembling odor of ammonia. The liquid boils at 20.3°F hence vaporizes rapidly when unconfined. Vapors are heavier than air and may collect in low-lying areas. Easily ignited under most conditions. Under prolonged exposure to intense heat the containers may rupture violently and rocket. Used for making pharmaceuticals, insecticides, paint removers, surfactants, rubber chemicals.
VAPOR: Irritating to eyes, nose and throat. If inhaled will cause coughing or difficult breathing. LIQUID: Will burn skin and eyes.
METHYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
colourless gas (or solution in water or methanol)
Dry the amine with sodium or BaO. It is commercially available in metal cylinders. [Beilstein 4 IV 118.]
Methylamine, also known as amino methane, is an important kind of organic chemical raw materials and intermediates and is a flammable colorless gas at normal temperature and pressure. Upon being liquefied or compressed at high concentrations, it has a strong odor of ammonia. It has fishy odor at very low concentrations. It is easily soluble in water and soluble in alcohol and ether. It is flammable and can form explosive mixtures with air with the explosive limit being 4.3% to 21%. It has weak alkalinity with the alkaline being stronger than ammonia. It can interact with inorganic acid to form water-soluble salts. It is obtained through the reaction between methanol and ammonia at high pressure and high temperature in the action of catalyst. Alternatively, it can be obtained through the reaction between formaldehyde and ammonium chloride upon being heated to 300 ℃ in the presence of zinc chloride. Methylamine can be used to make pesticides, pharmaceuticals, rubber vulcanization accelerator, dyes, explosives, leather, petroleum, surfactants, and ion exchange resin, paint strippers, and coatings as well as additives. It is an important raw material for the manufacturing of pesticide dimethoate, carbaryl, and chlordimeform. The inhalation toxicity of methylamine belongs to low toxicity category. The maximum allowable air concentration is 5mg/m3 (0.4ppm). It is corrosive and can cause irritation of the eyes, skin and mucous membranes. In case of fire, high heating temperature, it can cause risk of fire with cylinders and accessories damage being capable of causing an explosion.
Methylamine belongs to moderate-poisoning drug with a strong irritant and corrosive property. During the process of production and in transit, when there is leakage occurring due to accident, it can cause acute poisoning of contacted people.
This product can be subject to inhalation in its gaseous state from the respiratory tract. Its solution can be absorbed through the skin. Its salt can cause poisoning upon mistakenly oral administration. This product has a strong stimulating effect on eye; upper respiratory tract, skin and mucous membranes. Inhalation of it at high concentrations can cause damage to the lungs with people in severe cases getting pulmonary edema and respiratory distress syndrome, finally leading to death. However, it has been no yet reported of cases of systemic poisoning around the world. Liquid methylamine has strong irritation and corrosion effect and can cause eye and skin chemical burning. In case of 40% aqueous methylamine being splashed into the eyes, the victims can get burning eyes, photophobia, lacrimation, conjunctival hyperemia, eyelid irritation, corneal edema and superficial ulcers with those symptoms being able to last 1 to 2 weeks. Long-term exposure to low concentrations of methylamine can cause dryness and discomfort of the eyes, nose, and throat.
Upon skin contact, the victim should immediately remove the contaminated clothing, wash it thoroughly with a large amount of flowing water. For first-aid, the victim can apply 1 to 2% acetic acid, 0.5% citric acid to wash the skin, mucous membranes and mouth.
When the eyes are contaminated, they should raise the eyelid and wash the eyes with flowing clean water and saline for at least 15 minutes, followed by fluorescein staining. If there is corneal injury occurring, the victims should be invited to an ophthalmologist for treatment.
For patients inhaling nitric methylamine gas and getting poisoned, they should be rapidly transferred from the scene of fresh air and keep the airway open. For patients with breathing difficulties, they should be given oxygen. Patients of respiratory and cardiac arrest should be immediately subject to artificial respiration and sent to hospital immediately after treatment in a timely manner.
This information is edited by Xiongfeng Dai from Chemicalbook.
There are a lot of ways for manufacturing of methylamine. But in industry, people mainly apply methanol amination.
CH3OH + NH3 → CH3NH2 + H2O
2CH3OH + NH3 → (CH3) 2NH + 2H2O
3CH3OH + NH3 → (CH3) 3N + 3H2O
It is obtained through the following process: methanol and ammonia is at a ratio of 1.5 to 4 and subject to continuous vapor phase catalytic amination at high temperature and high pressure with activated alumina as a catalyst to generate the mixture crude product of mono-, di-, trimethylamine. The crude mixture further goes through a series of distillation column for continuous pressure and distillation separation, have cooling for deamination, dehydration can yield respectively mono-, di-, trimethylamine products.
Air & Water Reactions
Highly flammable. Very soluble in water; the solutions are strongly basic and therefore corrosive. Liquid fumes in air.