1012084-56-8

Basic information

• Product Name: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER
• Synonyms: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER;Pyridine, 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(2-Methylpyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 1012084-56-8
• Molecular Formula: C₁₂H₁₈BNO₂
• Molecular Weight: 219.08782
• Mol File: 1012084-56-8.mol

Chemical Properties

• Boiling Point: 311.6 °C at 760 mmHg
• Flash Point: 142.2 °C
• Appearance: /
• Density: 1.02 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.94±0.12(Predicted)
• CAS DataBase Reference: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER(1012084-56-8)
• EPA Substance Registry System: 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER(1012084-56-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 1012084-56-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-Methylpyridine-3-boronic acid pinacol ester is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, due to its ability to form carbon-carbon bonds through Suzuki-Miyaura coupling reactions, which is essential for constructing complex molecular structures.
Used in Organic Synthesis:
2-Methylpyridine-3-boronic acid pinacol ester is used as a reagent in organic synthesis for the preparation of heterocyclic compounds, which are important in the development of new drug candidates and functional materials.
Used as a Catalyst in Chemical Reactions:
2-Methylpyridine-3-boronic acid pinacol ester is used as a catalyst to enhance the efficiency of various chemical reactions, contributing to the advancement of synthetic methodologies in organic chemistry.
Used in the Development of New Drug Candidates:
2-Methylpyridine-3-boronic acid pinacol ester is used as a key intermediate in the development of new drug candidates, owing to its versatility in forming complex molecules that can target specific biological pathways.
Used in the Creation of Functional Materials:
2-Methylpyridine-3-boronic acid pinacol ester is used in the synthesis of functional materials with specific properties, such as conductivity, magnetism, or catalytic activity, which can be applied in various industries, including electronics, energy, and environmental protection.

InChI:InChI=1S/C12H18BNO2/c1-9-10(7-6-8-14-9)13-15-11(2,3)12(4,5)16-13/h6-8H,1-5H3

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 38749-79-0 3-bromo-2-picoline 

Downstream Products

• 1138419-62-1 6-(2-methyl-3-pyridinyl)-2-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 1448015-76-6 cyclopropanecarboxylic acid {4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amide 
• 1448015-73-3 (6-Methylpyridin-2-yl)-{4-[4-(2-methylpyridin-3-yl)phenyl]thiazol-2-yl}amine trifluoroacetate salt 
• 1620294-40-7 tert-butyl ((5-((2-(2-methylpyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate 
• 1620294-42-9 (5-((2-(2-methylpyridin-3-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride 
• 1951408-58-4 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 

Relevant articles and documents

Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle

The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one-pot borylation/Suzuki-Miyaura coupling (BSC) reaction with low catalyst loading (2 mol-%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step. Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki- Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. Copyright

IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES

The invention relates to imidazo[5,1-c][1,2,4]benzotriazine derivatives of formula I: which are inhibitors of phosphodiesterase 2 or 10 useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type 2 diabetes, metabolic syndrome, glucose intolerance, and pain.

Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10

The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical compositions which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating central nervous system disorders, obesity, and metabolic disorders.

ARYL AND HETEROARYL FUSED IMIDAZO[1,5-a]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10

The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.