101350-41-8

Basic information

• Product Name: 2-benzyl-5-(4-methylphenyl)-1,3,4-oxadiazole
• Synonyms: 2-benzyl-5-(4-methylphenyl)-1,3,4-oxadiazole
• CAS NO: 101350-41-8
• Molecular Weight: 250.3
• Mol File: 101350-41-8.mol

Chemical Properties

• CAS DataBase Reference: 2-benzyl-5-(4-methylphenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-5-(4-methylphenyl)-1,3,4-oxadiazole(101350-41-8)
• EPA Substance Registry System: 2-benzyl-5-(4-methylphenyl)-1,3,4-oxadiazole(101350-41-8)

Safety Data

• Hazardous Substances Data: 101350-41-8(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 18489-25-3 5-benzyl-2H-tetrazole 
• 18489-25-3 5-benzyl-1H-tetrazole 
• 13222-85-0 p-methylbenzoic anhydride 
• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 13326-10-8 benzyl methyl carbonate 
• 119072-55-8 tert-butylisonitrile 
• 624-31-7 4-tolyl iodide 
• 937-39-3 2-phenylacetylhydrazine 

Relevant articles and documents

The preparation, characterization and catalytic activity of Ni NPs supported on porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide)

Herein, we report the synthesis of nickel nanoparticles under mild conditions using porous alginate-g-poly(p-styrene sulfonamide-co-acrylamide) as a protecting/stabilizing agent and sodium borohydride as a reducing agent. The porous cross-linked polymeric support was preparedviacombining the use of sol-gel, nanocasting, and crosslinking techniques, in which thep-styrene sulfonamide monomer (PSSA) andN,N′-methylene-bis (acrylamide) (MBA) cross-linker underwent copolymerization on the surface of sodium alginate in the presence of a SiO2nanoparticle (NP) template (Alg-PSSA-co-ACA). The prepared catalyst (Alg-PSSA-co-ACA@Ni) showed high catalytic activity for the one-step synthesis of 1,3,4-oxadiazoles from the reaction of hydrazides and aryl iodides through isocyanide insertion/cyclization.

Palladium-catalyzed direct benzylation of azoles with benzyl carbonates

"Chemical Equation Presented" The direct aromatic sp2 C-H benzylation of azole compounds with benzyl carbonates proceeds efficiently in the presence of a Pd2(dba)3/dppp catalyst system and KaOAc as a base to afford the corresponding diarylmethanes in good yields. In addition, the same palladium catalyst enables the direct benzylic sp3 C-H benzylation with the second benzyl carbonates without employing any external base.

TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES

Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.