101463-69-8

Basic information

• Product Name: Flufenoxuron
• Synonyms: N-[4-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-2-FLUOROPHENYLAMINOCARBONYL]-2,6-DIFLUORO-BENZAMIDE;CASCADE;FLUFENOXURON;6-difluoro-rbonyl)-;benzamide,n-(((4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl)amino)ca;fluorobenzamide;n-((4-(2-chloro-4-(trifluoromethyl)phenoxy)-2-fluorophenyl)carbamoyl)-2,6-di;wl115110
• CAS NO: 101463-69-8
• Molecular Formula: C₂₁H₁₁ClF₆N₂O₃
• Molecular Weight: 488.77
• EINECS: 417-680-3
• Mol File: 101463-69-8.mol

Chemical Properties

• Melting Point: 169-172° (dec)
• Appearance: /
• Density: 1.5123 (estimate)
• Vapor Pressure: 6.52 x l0-12 Pa (20 °C)
• Refractive Index: 1.573
• Storage Temp.: 0-6°C
• Solubility: Benzene (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Sparingly)
• PKA: 8.68±0.46(Predicted)
• Water Solubility: 4 x l0-6 mg l-1(25 °C)
• BRN: 8398323
• CAS DataBase Reference: Flufenoxuron(CAS DataBase Reference)
• NIST Chemistry Reference: Flufenoxuron(101463-69-8)
• EPA Substance Registry System: Flufenoxuron(101463-69-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20
• Safety Statements: 22
• RIDADR: 3077
• WGK Germany: 2
• RTECS: CV2474500
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 101463-69-8(Hazardous Substances Data)

Usage

Uses

Used in Agriculture:
Flufenoxuron is used as an insecticide and mite growth regulator for the control of various phytophagous mites (Aculus, Brevipalpus, Panonychus, Phyllocoptuuta, Tetranychus, spp) and insect pests on a wide range of crops. These crops include pome fruit, vines, citrus, tea, cotton, maize, vegetables, and ornamentals. By targeting the chitin synthesis in these pests, Flufenoxuron helps protect plants from damage and enhances crop yield and quality.
Used in Public Hygiene:
Flufenoxuron is also utilized as a public hygiene insecticide, playing a crucial role in controlling insect populations that can pose health risks to humans and animals. By disrupting the growth and development of insects, Flufenoxuron helps maintain a cleaner and safer environment, reducing the spread of diseases and the need for other, potentially more harmful, pest control methods.

Metabolic pathway

Information on the metabolism of flufenoxuron is avilable in a Pesticides Safety Directorate review of its use as a public hygiene insecticide (PSD).

Degradation

The DT50 of flufenoxuron (25 °C) was 267 days at pH 7,206 days at pH 5 and 36.7 days at pH 9 (PM). Flufenoxuron underwent photodegradation to form 2,6-difluorobenzamide (2), the urea derivative 3 and the 4-aminodiphenyl ether 4 in aqueous solution under natural sunlight in the UK (PSD, 1995).

Mode of action

Flufenoxuron acts in a similar manner to diflubenzuron, reducing chitin incorporation in the cuticJe (Clarke and Jewess 1990). It has cuticular and stomach action. It has ovo-Iarvicidal activity. Treated adults lay non-viable eggs (Tomlin 1995).

InChI:InChI=1/C21H11ClF6N2O3/c22-12-8-10(21(26,27)28)4-7-17(12)33-11-5-6-16(15(25)9-11)29-20(32)30-19(31)18-13(23)2-1-3-14(18)24/h1-9H,(H2,29,30,31,32)

Downstream Products

• 229178-78-3 1-[4-(2-chloro-α,α,α-trifluoro-4-tolyloxy)-2-fluorophenyl]-3-[2,6-difluoro-3-(2-ethoxycarbonylethyl)benzoyl]urea 
• 229178-79-4 1-[4-(2-chloro-α,α,α-trifluoro-4-tolyloxy)-2-fluorophenyl]-3-[2,6-difluoro-3-(2-carbonylethyl)benzoyl]urea 

Related news

Liquid chromatography with tandem mass spectrometry for the determination of Flufenoxuron (cas 101463-69-8) in blood using automatic solid phase extraction and its application to a fatal case of Flufenoxuron (cas 101463-69-8) poisoning07/13/2019

A liquid chromatography/tandem mass spectrometry method with solid phase extraction for the detection and the quantitation of flufenoxuron in an aliquot of blood was developed and validated. Flufenoxuron belongs to a benzoylurea insecticide and is the active ingredient of Cascade™. The analyte i...detailed

Unraveling the different toxic effect of Flufenoxuron (cas 101463-69-8) on the thyroid endocrine system of the Mongolia racerunner (Eremias Argus) at different stages07/12/2019

Flufenoxuron is a widely used pesticide to inhibit the synthesis of chitin during insect development and its effect on the growth of lizards has been little addressed. The hypothalamus-pituitary-thyroid (HPT) axis plays an important role on the development of lizards. In this study, the lizards ...detailed

Dose-dependent effects of Flufenoxuron (cas 101463-69-8) on thyroid system of mature female lizards (Eremias argus) and their offspring07/11/2019

More and more studies are focusing on toxic effect of pesticides on lizards. However, the responses of different life-stage lizards to pesticides have not been reported. In this study, according to RNA-seq library data, thyroxine 5′-deiodinase activity showed significant difference between matu...detailed

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