Flufenoxuron

Base Information

• Chemical Name: Flufenoxuron
• CAS No.: 101463-69-8
• Molecular Formula: C21H11ClF6N2O3
• Molecular Weight: 488.773
• European Community (EC) Number: 417-680-3,600-215-5
• UNII: OD068OSS0N
• DSSTox Substance ID: DTXSID1041978
• Nikkaji Number: J228.145G
• Wikipedia: Flufenoxuron
• Wikidata: Q2787491
• Metabolomics Workbench ID: 56274
• ChEMBL ID: CHEMBL2287680
• Mol file: 101463-69-8.mol

Synonyms:1-(4-(2-chloro-4-(trifluromethyl)phenoxy)-2-fluorophenyl)-3-(2,6-difluorobenzoyl)urea;flufenoxuron

Chemical Property of Flufenoxuron

Chemical Property:

• Vapor Pressure: 6.52 x l0-12 Pa (20 °C)
• Melting Point: 169-172° (dec)
• Refractive Index: 1.573
• PKA: 8.68±0.46(Predicted)
• PSA: 67.43000
• Density: 1.53 g/cm³
• LogP: 6.99420
• Storage Temp.: 0-6°C
• Solubility.: Benzene (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Sparingly)
• Water Solubility.: 4 x l0-6 mg l-1(25 °C)
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 488.0362389
• Heavy Atom Count: 33
• Complexity: 689

Purity/Quality:

99% ^*data from raw suppliers

Flufenoxuron ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20
• Safety Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=C(C=C(C=C2)OC3=C(C=C(C=C3)C(F)(F)F)Cl)F)F
• Uses: Flufenoxuron is an known insecticide and acts as an insect growth regulator by inhibiting chitin synthesis. Flufenoxuron is used for the control of many phytophagous mites (Aculus, Brevipalpus, Pananychus, Phyllocoptuuta, Tetuanychus, spp) and insect pests on pome fruit, vines, citrus, tea, cotton, maize, vegetables and ornamentals. It is also used as a public hygiene insecticide.

Technology Process of Flufenoxuron

There total 1 articles about Flufenoxuron which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ flufenoxuron (101463-69-8)

Guidance literature:

Reference yield: 50.7%

PhCH2O2CN(CH2Cl)2 + flufenoxuron (101463-69-8) → 5-benzyloxycarbonyl-1-[4-(2-chloro-4-trifluoromethylphenoxy)-2-fluorophenyl]-3-(2,6-difluorobenzoyl)tetrahydro-1,3,5-triazin-2(1H)-one

Guidance literature:

flufenoxuron; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 3 ℃; for 0.5h;

PhCH₂O₂CN(CH₂Cl)2; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); at 1 - 20 ℃; for 1.5h;

Reference yield: 13.0%

flufenoxuron (101463-69-8) → N-[[4-[2-chloro-4-(bromodifluoromethyl)phenoxy]-2-fluorophenyl]aminocarbonyl]-2,6-difluorobenzamide

Guidance literature:

With iron(III) trifluoride; boron tribromide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1002/chem.202101324

Downstream raw materials:

1-[4-(2-chloro-α,α,α-trifluoro-4-tolyloxy)-2-fluorophenyl]-3-[2,6-difluoro-3-(2-carbonylethyl)benzoyl]urea

1-[4-(2-chloro-α,α,α-trifluoro-4-tolyloxy)-2-fluorophenyl]-3-[2,6-difluoro-3-(2-ethoxycarbonylethyl)benzoyl]urea

Refernces

• 1、 -. "Method for the preparation of insecticidal benzoylurea compounds". . . Retrieved 2008/06/13.