- Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation
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Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.
- Katayev,Václavík,Brüning,Commare,Togni
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Read Online
- Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives
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Deregulation of c-Met receptor tyrosine kinase activity leads to tumorigenesis and metastasis in animal models. More importantly, the identification of activating mutations in c-Met, as well as MET gene amplification in human cancers, points to c-Met as a
- Norman, Mark H.,Liu, Longbin,Lee, Matthew,Xi, Ning,Fellows, Ingrid,D'Angelo, Noel D.,Dominguez, Celia,Rex, Karen,Bellon, Steven F.,Kim, Tae-Seong,Dussault, Isabelle
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experimental part
p. 1858 - 1867
(2012/05/05)
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- Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
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Provided herein are Heterocyclic Compounds having the following structure: wherein R1, R2, X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.
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Page/Page column 55
(2008/12/07)
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