The hydroxylation of Δ5-androstenes by Cephalosporium aphidicola
Whereas the major hydroxylation product of 3β-hydroxy-5α-androstan- 17-one by Cephalosporium aphidicola is the 11α-alcohol, the presence of a Δ5-double bond in the substrate leads to non-stereospecific allylic hydroxylation at C-7. Hydroxylation at C-11 became a minor transformation and there was no detectable hydroxylation at C-14.
Bensasson, Caroline M.,Hanson, James R.,Hunter, A. Christy
The microbiological hydroxylation of 3α,5-cycloandrostanes by Cephalosporium aphidicola
The microbiological hydroxylation of some 3α,5-cycloandrostanes by the fungus, Cephalosporium aphidicola has been shown to take place at C-2α and C-14α and a 6β-alcohol was oxidized to the 6-ketone.
Bensasson, Caroline S.,Hanson, James R.,Le Huerou, Yvan
p. 1279 - 1282
(2007/10/03)
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