Branched-selective intermolecular ketone α-alkylation with unactivated alkenes via an enamide directing strategy
We describe a strategy for intermolecular branched-selective α-alkylation of ketones using simple alkenes as the alkylating agents. Enamides derived from isoindolin-1-one provide an excellent directing template for catalytic activation of ketone α-positions. High branched selectivity is obtained for both aliphatic and aromatic alkenes using a cationic iridium catalyst. Preliminary mechanistic study favors an Ir-C migratory insertion pathway.
Xing, Dong,Dong, Guangbin
supporting information
p. 13664 - 13667
(2017/11/07)
Chemo- and diastereoselective Bi(OTf)3-catalyzed benzylation of silyl nucleophiles
The direct alkylation of silyl enol ethers with para-methoxybenzylic alcohols or their corresponding acetates was efficiently catalyzed by Bi(OTf)3 in CH3NO2 as the solvent. The reaction provided the α-benzylated carbonyl
Rubenbauer, Philipp,Bach, Thorsten
p. 1305 - 1309
(2008/09/18)
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