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Methyl 4-methoxynicotinate, a chemical compound with the molecular formula C8H9NO3, is a derivative of nicotinic acid. It is recognized for its vasodilatory, anti-inflammatory, antioxidant, and neuroprotective properties, making it a valuable intermediate in pharmaceutical synthesis and a promising candidate for the treatment of various conditions.

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  • 10177-32-9 Structure
  • Basic information

    1. Product Name: METHYL4-METHOXYNICOTINATE
    2. Synonyms: 4-Methoxy-3-pyridinecarboxylic acid methyl ester;METHYL4-METHOXYNICOTINATE;Methyl 4-methoxypyridine-3-carboxylate;4-Methoxypyridine-3-carboxylic acid mehyl ester;Methyl 4-Methoxypyridin-3-carboxylate;Methyl 4-methoxypyridine-3-carboxylate, 4-Methoxy-3-(methoxycarbonyl)pyridine
    3. CAS NO:10177-32-9
    4. Molecular Formula: C8H9NO3
    5. Molecular Weight: 167.17
    6. EINECS: N/A
    7. Product Categories: blocks;Carboxes;Pyridines;Esters
    8. Mol File: 10177-32-9.mol
  • Chemical Properties

    1. Melting Point: 83-84 °C
    2. Boiling Point: 250.891°C at 760 mmHg
    3. Flash Point: 105.535°C
    4. Appearance: /
    5. Density: 1.156g/cm3
    6. Vapor Pressure: 0.021mmHg at 25°C
    7. Refractive Index: 1.504
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: N/A
    10. PKA: 4.51±0.18(Predicted)
    11. CAS DataBase Reference: METHYL4-METHOXYNICOTINATE(CAS DataBase Reference)
    12. NIST Chemistry Reference: METHYL4-METHOXYNICOTINATE(10177-32-9)
    13. EPA Substance Registry System: METHYL4-METHOXYNICOTINATE(10177-32-9)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 10177-32-9(Hazardous Substances Data)

10177-32-9 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-methoxynicotinate is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Cardiovascular Disease Treatment:
Methyl 4-methoxynicotinate is used as a vasodilator for its capacity to improve blood flow and potentially treat cardiovascular diseases by reducing the strain on the heart.
Used in Inflammatory Condition Treatment:
Due to its anti-inflammatory properties, Methyl 4-methoxynicotinate is used in the treatment of inflammatory conditions to alleviate symptoms and reduce inflammation.
Used in Medicinal Chemistry and Drug Development:
Methyl 4-methoxynicotinate is used as a compound of interest in medicinal chemistry and drug development for its antioxidant and neuroprotective effects, which may contribute to the development of treatments for neurodegenerative diseases and other conditions where oxidative stress plays a role.

Check Digit Verification of cas no

The CAS Registry Mumber 10177-32-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,7 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10177-32:
(7*1)+(6*0)+(5*1)+(4*7)+(3*7)+(2*3)+(1*2)=69
69 % 10 = 9
So 10177-32-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3/c1-11-7-3-4-9-5-6(7)8(10)12-2/h3-5H,1-2H3

10177-32-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 4-Methoxynicotinate

1.2 Other means of identification

Product number -
Other names Methyl 4-methoxynicotinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10177-32-9 SDS

10177-32-9Relevant articles and documents

The Reaction of N -Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol to Access Diheteroarylamides

Koperniku, Ana,Zamiri, Maryam,Grierson, David S.

, p. 1779 - 1790 (2019)

The S -benzyl thioester and methyl ester derivatives of a representative 4-pyridinone-based carboxylic acid were sufficiently activated to react efficiently in amide coupling reactions with the amide anion generated in situ from the N -trimethylsilyl derivative of different weakly nucleophilic heteroarylamines. In acetonitrile as solvent, the precipitated diheteroarylamide products were isolated in pure form by vacuum filtration. This simple amide bond forming protocol can be readily adapted to the parallel synthesis of compound libraries.

Syntheses of ortho-hydroxymethylpyridinols and dioxaphosphorino[m,n-x]pyridines

Leroy,Despres,Bigan,Blondeau

, p. 2257 - 2272 (2007/10/03)

Dioxaphosphorino[m,n-x]pyridines compounds have been prepared by condensation of methyl dichlorophosphate with new ortho-hydroxymethylpyridinols.

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