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High Purity methyl alcohol
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67-56-1 Usage


Suitable for HPLC, spectrophotometry, and some LC-MS applications


Methanol is the simplest fatty alcohol. It is a colorless, flammable, irritating liquid with a boiling point of 64.7°C, a melting point of -93.90°C, and a relative density of 0.7913. Soluble in water and most organic solvents. Its severe toxicity can damage the optic nerve. Once swallowed, it can make the eyes blind and even cause death.
Methanol has the general properties of a primary aliphatic alcohol. The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. Therefore, it is largely used in the synthesis of formaldehyde. Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and methylamine, and it is also applied as important organic solvents, extraction agents and alcohol denaturants.


Methanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce acetic anhydride. It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in medicine and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester.
Industry Applications Role/Benefit
Laboratory HPLC, UV/VIS spectroscopy, and LCMS Low UV cutoff
Chemical manufacture Production of formaldehyde and its derivates Main feedstock
Production of hydrocarbon chains and even aromatic systems Main feedstock
Production of methyl tert-butyl ether Methylation reagent
Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester Main feedstock
Plastics Production of polymers Main feedstock
Farm chemical Production of insecticide and acaricide Main feedstock
Pharmaceuticals Production of sulfonamides, amycin, etc Main feedstock
Fuel for vehicles Pure methanol fuel Pure methanol does not produce an opaque cloud of smoke in the event of an accident
Methanol gasoline Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline
Chemical analysis Determination of boron Analysis agent
Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine Analysis agent
Others Separation of calcium sulfate and magnesium sulfate Separation reagent
Separation of strontium bromide and barium bromide Separation reagent
Anti-freezing agent Effective component

Reactivities of Methanol

Methanol is the simplest aliphatic alcohol. It contains only one carbon atom. Unlike higher alcohols, it cannot form an olefin through dehydration. However, it can undergo other typical reactions of aliphatic alcohols involving cleavage of a C-H bond or O-H bond and displacement of the -OH group. Table 1 summarizes the reactions of methanol, which are classified in terms of their mechanisms. Examples of the reactions and products are given.

Homolytic dissociation energies of the C-O and O-H bonds in methanol are relatively high. Catalysts are often used to activate the bonds and to increase the selectivity to desired products.

Purification Methods

Almost all methanol is now obtained synthetically. Likely impurities are water, acetone, formaldehyde, ethanol, methyl formate and traces of dimethyl ether, methylal, methyl acetate, acetaldehyde, carbon dioxide and ammonia. Most of the water (down to about 0.01%) can be removed by fractional distillation. Drying with CaO is unnecessary and wasteful. Anhydrous methanol can be obtained from "absolute" material by passage through Linde type 4A molecular sieves, or by drying with CaH2, CaSO4, or with just a little more sodium than required to react with the water present, in all cases the methanol is then distilled. Two treatments with sodium reduces the water content to about 5 x 10-5%. [Friedman et al. J Am Chem Soc 83 4050 1961.] Lund and Bjerrum [Chem Ber 64 210 1931] warmed clean dry magnesium turnings (5g) and iodine (0.5g) with 50-75mL of "absolute" methanol in a flask until the iodine disappeared and all the magnesium was converted to the methoxide. Up to 1L of methanol was added and, after refluxing for 2-3hours, it was distilled off, excluding moisture from the system. Redistillation from tribromobenzoic acid removes basic impurities and traces of magnesium oxides, and leaves conductivity-quality material. The method of Hartley and Raikes [J Chem Soc 127 524 1925] gives a slightly better product. This consists of an initial fractional distillation, followed by distillation from aluminium methoxide, and then ammonia and other volatile impurities are removed by refluxing for 6hours with freshly dehydrated CuSO4 (2g/L) while dry air is passed through: the methanol is finally distilled. (The aluminium methoxide is prepared by warming with aluminium amalgam (3g/L) until all the aluminium has reacted. The amalgam is obtained by warming pieces of sheet aluminium with a solution of HgCl2 in dry methanol.) This treatment also removes aldehydes. If acetone is present in the methanol, it is usually removed prior to drying. Bates, Mullaly and Hartley [J Chem Soc 401 1923] dissolved 25g of iodine in 1L of methanol and then poured the solution, with constant stirring, into 500mL of M NaOH. Addition of 150mL of water precipitated iodoform. The solution was allowed to stand overnight, filtered, then boiled under reflux until the odour of iodoform disappeared, and fractionally distilled. (This treatment also removes formaldehyde.) Morton and Mark [Ind Eng Chem (Anal Edn) 6 151 1934] refluxed methanol (1L) with furfural (50mL) and 10% NaOH solution (120mL) for 6-12hours, the refluxing resin carries down with it the acetone and other carbonyl-containing impurities. The alcohol was then fractionally distilled. Evers and Knox [J Am Chem Soc 73 1739 1951], after refluxing 4.5L of methanol for 24hours with 50g of magnesium, distilled off 4L of it, which they then refluxed with AgNO3 for 24hours in the absence of moisture or CO2. The methanol was again distilled, shaken for 24hours with activated alumina before being filtered through a glass sinter and distilled under nitrogen in an all-glass still. Material suitable for conductivity work was obtained. Variations of the above methods have also been used. For example, a sodium hydroxide solution containing iodine has been added to methanol and, after standing for 1day, the solution has been poured slowly into about a quarter of its volume of 10% AgNO3, shaken for several hours, then distilled. Sulfanilic acid has been used instead of tribromobenzoic acid in Lund and Bjerrum's method. A solution of 15g of magnesium in 500mL of methanol has been heated under reflux, under nitrogen, with hydroquinone (30g), before degassing and distilling the methanol, which was subsequently stored with magnesium (2g) and hydroquinone (4g per 100mL). Refluxing for about 12hours removes the bulk of the formaldehyde from methanol: further purification has been obtained by subsequent distillation, refluxing for 12hours with dinitrophenylhydrazine (5g) and H2SO4 (2g/L), and again fractionally distilling. [Beilstein 1 IV 1227.]

Reactivity Profile

Methanol reacts violently with acetyl bromide [Merck 11th ed. 1989]. Mixtures with concentrated sulfuric acid and concentrated hydrogen peroxide can cause explosions. Reacts with hypochlorous acid either in water solution or mixed water/carbon tetrachloride solution to give methyl hypochlorite, which decomposes in the cold and may explode on exposure to sunlight or heat. Gives the same product with chlorine. Can react explosively with isocyanates under basic conditions. The presence of an inert solvent mitigates this reaction [Wischmeyer 1969]. A violent exothermic reaction occurred between methyl alcohol and bromine in a mixing cylinder [MCA Case History 1863. 1972]. A flask of anhydrous lead perchlorate dissolved in Methanol exploded when Methanol was disturbed [J. Am. Chem. Soc. 52:2391. 1930]. P4O6 reacts violently with Methanol. (Thorpe, T. E. et al., J. Chem. Soc., 1890, 57, 569-573). Ethanol or Methanol can ignite on contact with a platinum-black catalyst. (Urben 1794).


high purity grade for ICP-MS detection

Methanol gasoline

Methanol gasoline refers to the M series mixture fuel made of addition of methanol to the gasoline and formulated using methanol fuel solvent. Among them, M15 (add 15% methanol in gasoline) clean methanol gasoline is used as vehicle fuel, respectively, used in a variety of gasoline engines. It can be applied to substitute the finished gasoline without changing the existing engine structure, and can also be mixed with refined oil. The methanol mixed fuel has excellent thermal efficiency, power, start-up and being economical. It is also characterized by lowering the emissions, saving oil and being safe and convenient. Methanol gasoline types of M35, M15, M20, M50, N85 and M100 with different blend ratios have been developed around the world according to the conditions of different countries. At present, the commercial methanol is mainly M85 (85% methanol + 15% gasoline) and M100 with M100 performance being better than M85 and having greater environmental advantages.


Industrial solvent. Raw material for making formaldehyde and methyl esters of organic and inorganic acids. Antifreeze for automotive radiators and air brakes; ingredient of gasoline and diesel oil antifreezes. Octane booster in gasoline. As fuel for picnic stoves and soldering torches. Extractant for animal and vegetable oils. To denature ethanol. Softening agent for pyroxylin plastics. Solvent and solvent adjuvant for polymers. Solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals.


Meets ACS specifications


  • Methanol is prepared by pressure heating with carbon monoxide and hydrogen in the presence of a catalyst:
If the conditions are strictly controlled, the yield can reach 100% and the purity can reach 99%.
  • Methane is mixed with oxygen (9:1, V/V) and methanol is obtained through a copper tube under heating and pressure:

Fire Hazard

Behavior in Fire: Containers may explode.

Health Hazard

Exposure to excessive vapor causes eye irritation, head- ache, fatigue and drowsiness. High concentrations can produce central nervous system depression and optic nerve damage. 50,000 ppm will probably cause death in 1 to 2 hrs. Can be absorbed through skin. Swallowing may cause death or eye damage.

General Description

A colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Completely mixes with water. The vapors are slightly heavier than air and may travel some distance to a source of ignition and flash back. Any accumulation of vapors in confined spaces, such as buildings or sewers, may explode if ignited. Used to make chemicals, to remove water from automotive and aviation fuels, as a solvent for paints and plastics, and as an ingredient in a wide variety of products.

Methanol poisoning and First Aid Measures

First, methanol has a cumulative effect and is oxidized in the body into more toxic formaldehyde and formic acid. Methanol and its oxides directly damage the tissues, causing cerebral edema, meningeal hemorrhage, optic nerve and retinal atrophy, pulmonary congestion and edema, and hepatic and renal turbid swelling.
Second, methanol and its oxides cause blood circulation disorder, coenzyme system obstacles in vivo, resulting in lack of oxygen supply to the brain cortical cells, metabolic disorders, and related neurological and psychiatric symptoms.
Third, methanol oxidation products combine with the iron in the cytochrome oxidase, which inhibits the intracellular oxidation process thus causing metabolic disorders, acidosis along with organic acid accumulation in the body, and nerve cells impair.

  • Keep away from the methanol dispersion area, excrete methanol from the body.
    Antidote: Ethanol is an antidote to methanol poisoning. Ethanol can prevent methanol’s oxidation and promote its emission. Prepare 5% ethanol solution using 10% glucose solution, and drip slowly intravenously.
  • Maintain electrolyte balance: maintain respiratory and circulatory function, provide with a large number of Vitamin B.
    Treatment of acidosis: Administrate timely sodium bicarbonate solution or sodium lactate solution based on blood gas analysis, carbon dioxide binding force measurement and clinical performance.
  • Prevent cerebral edemas actively, reduce intracranial pressure, improve fundus blood circulation, and prevent optic neuropathy if needed.
  • Inject intravenously cytochrome C, polar fluid to restore cytochrome oxidase function.
  • Control mental state by applying diazepam, perphenazine and the like.
Symptoms and treatments:
Acute pain morphine, pethidine
Convulsions phenobarbital, amimystrine, diazepam
Coma caffeine sodium benzoate
Respiratory failure nikethamide, theophylline


ChEBI: The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.


ADI is limited to GMP (FAO/WHO, 2001).
Toxic, can cause blindness.
LD50: 5628 mg/kg (rat, oral).
Measurement Date System Route/Organism Dose Effect
Skin and Eye Irritation December 2016   eye /rabbit 40 mg moderate
Skin and Eye Irritation December 2016   eye /rabbit 100 mg/24H moderate
Skin and Eye Irritation December 2016   skin /rabbit 20 mg/24H moderate
Mutation Data December 2016 Cytogenetic Analysis parenteral/grasshopper 3000 ppm  
Mutation Data December 2016 Cytogenetic Analysis oral/mouse 1 gm/kg  
Mutation Data December 2016 Cytogenetic Analysis intraperitoneal/mouse 75 mg/kg  
Mutation Data December 2016 DNA Damage oral/rat 10 µmol/kg  
Mutation Data December 2016 DNA inhibition lymphocyte/human 300 mmol/L  
Mutation Data December 2016 DNA repair /Escherichia coli 20 mg/well  
Mutation Data December 2016 morphological transform fibroblast/mouse 0.01 mg/L/21D (-enzymatic activation step)  
from The National Institute for Occupational Safety and Health - NIOSH


Methylalcohol, CH30H, also known as methanol or wood alcohol, is a colorless, toxic, flammable liquid with a boiling point of 64.6 °C(147 °F). The principal toxic effect is on the nervous system,particularly the retinae. Methyl alcoholis miscible in all proportions with water,ethyl alcohol, and ether. It burns with a light blue flame producing water and carbon dioxide. This vapor forms an explosive mixture(6.0 to 36.5% by volume) with air. Methyl alcohol is an important inexpensive raw material that is synthetically produced for the organic chemical industry. Nearly half of the methyl alcohol manufactured is used in the production of formaldehyde. Other uses of methyl alcohol are as an antifreeze and fuel for automobiles and as an intermediate in the production of synthetic protein.

67-56-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (NISTRM8509)  Moisture in methanol, 93 mg/kg  NIST® SRM® 8509 67-56-1 NISTRM8509 8,867.43CNY Detail
Sigma-Aldrich (NISTRM8510)  Moisture in methanol, 325 mg/kg  NIST® SRM® 8510 67-56-1 NISTRM8510 8,867.43CNY Detail
USP (1601623)  Residual Solvent Class 2 - Methanol  United States Pharmacopeia (USP) Reference Standard 67-56-1 1601623-3X1.2ML 4,662.45CNY Detail
USP (1424109)  Methylalcohol  United States Pharmacopeia (USP) Reference Standard 67-56-1 1424109-3AMP 4,662.45CNY Detail
Aldrich (721956)  Methanolsolution  NMR reference standard, 4% in methanol-d4 (99.8 atom % D), NMR tube size 3 mm × 8 in. 67-56-1 721956-8IN 2,215.98CNY Detail
Aldrich (721964)  Methanolsolution  NMR reference standard, 4% in methanol-d4 (99.8 atom % D), NMR tube size 5 mm × 8 in. 67-56-1 721964-8IN 2,215.98CNY Detail
Aldrich (717975)  Methanol  NMR reference standard 67-56-1 717975-8IN 1,501.11CNY Detail
Sigma-Aldrich (M1775)  Methanol  Absolute - Acetone free 67-56-1 M1775-1GA 1,308.06CNY Detail
Sigma-Aldrich (82762)  Methanol  analytical standard 67-56-1 82762-10ML-F 772.20CNY Detail
Sigma-Aldrich (82762)  Methanol  analytical standard 67-56-1 82762-1ML-F 157.95CNY Detail
Fluka (34802)  HYDRANAL®-Water-in-methanol5.0  for volumetric back titration according to Karl Fischer, 5.00 mg/mL±0.05 mg/mL in methanol 67-56-1 34802-1L 554.58CNY Detail
Fluka (34802)  HYDRANAL®-Water-in-methanol5.0  for volumetric back titration according to Karl Fischer, 5.00 mg/mL±0.05 mg/mL in methanol 67-56-1 34802-500ML 404.82CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name methanol

1.2 Other means of identification

Product number -
Other names methyl alcohol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Methanol is primarily used as an industrial solvent for inks, resins, adhesives, and dyes. It is also used as a solvent in the manufacture of cholesterol, streptomycin, vitamins, hormones, and other pharmaceuticals. (-) Methanol is also used as an antifreeze for automotive radiators, an ingredient of gasoline (as an antifreezing agent and octane booster), and as fuel for picnic stoves. Methanol is also an ingredient in paint and varnish removers. (-) Methanol is also used as an alternative motor fuel.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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