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1018856-48-8

C10H11N2O3S2(1-)*K(1+) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1018856-48-8 Structure

  • Basic information

    1. Product Name: C10H11N2O3S2(1-)*K(1+)
    2. Synonyms: C10H11N2O3S2(1-)*K(1+)
    3. CAS NO:1018856-48-8
    4. Molecular Formula:
    5. Molecular Weight: 310.439
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1018856-48-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C10H11N2O3S2(1-)*K(1+)(CAS DataBase Reference)
    10. NIST Chemistry Reference: C10H11N2O3S2(1-)*K(1+)(1018856-48-8)
    11. EPA Substance Registry System: C10H11N2O3S2(1-)*K(1+)(1018856-48-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1018856-48-8(Hazardous Substances Data)

1018856-48-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1018856-48-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,8,5 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1018856-48:
(9*1)+(8*0)+(7*1)+(6*8)+(5*8)+(4*5)+(3*6)+(2*4)+(1*8)=158
158 % 10 = 8
So 1018856-48-8 is a valid CAS Registry Number.

1018856-48-8Downstream Products

1018856-48-8Relevant articles and documents

PHOSPHODIESTERASE INHIBITORS

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Page/Page column 38, (2009/09/04)

The invention relates to compounds of formula I useful for inhibiting phosphodiesterase-4

Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors

Skoumbourdis, Amanda P.,LeClair, Christopher A.,Stefan, Eduard,Turjanski, Adrian G.,Maguire, William,Titus, Steven A.,Huang, Ruili,Auld, Douglas S.,Inglese, James,Austin, Christopher P.,Michnick, Stephen W.,Xia, Menghang,Thomas, Craig J.

supporting information; experimental part, p. 3686 - 3692 (2010/03/24)

An expansion of structure-activity studies on a series of substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine PDE4 inhibitors and the introduction of a related [1,2,4]triazolo[4,3-b]pyridazine based inhibitor of PDE4 is presented. The development of SAR included strategic incorporation of known substituents on the critical catachol diether moiety of the 6-phenyl appendage on each heterocyclic core. From these studies, (R)-3-(2,5-dimethoxyphenyl)-6-(4-methoxy-3-(tetrahydrofuran-3-yloxy)phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (10) and (R)-3-(2,5-dimethoxyphenyl)-6-(4-methoxy-3-(tetrahydrofuran-3-yloxy)phenyl)-[1,2,4]triazolo[4,3-b]pyridazine (18) were identified as highly potent PDE4A inhibitors. Each of these analogues was submitted across a panel of 21 PDE family members and was shown to be highly selective for PDE4 isoforms (PDE4A, PDE4B, PDE4C, PDE4D). Both 10 and 18 were then evaluated in divergent cell-based assays to assess their relevant use as probes of PDE4 activity. Finally, docking studies with selective ligands (including 10 and 18) were undertaken to better understand this chemotypes ability to bind and inhibit PDE4 selectively.

Identification of a potent new chemotype for the selective inhibition of PDE4

Skoumbourdis, Amanda P.,Huang, Ruili,Southall, Noel,Leister, William,Guo, Vicky,Cho, Ming-Hsuang,Inglese, James,Nirenberg, Marshall,Austin, Christopher P.,Xia, Menghang,Thomas, Craig J.

, p. 1297 - 1303 (2008/09/20)

A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.

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