Total synthesis of the alkaloid (±)-aspidophytine based on carbonyl ylide cycloaddition chemistry
The RhII-catalyzed cycloaddition cascade of an indolyl-substituted α-diazo imide was used for the total synthesis of the complex pentacyclic alkaloid (±)-aspidophytine. Treatment of the resulting dipolar cycloadduct with BF3·OEt
Application of the Rh(II) cyclization/cycloaddition cascade for the total synthesis of (±)-aspidophytine
A new strategy for the synthesis of (±)-aspidophytine has been developed and is based on a Rh(II)-catalyzed cyclization/dipolar cycloaddition sequence. The resulting [3+2]-cycloadduct undergoes an efficient Lewis acid mediated cascade that rapidly provide