1117-71-1

Basic information

• Product Name: Methyl 4-bromocrotonate
• Synonyms: methylbromocrotonate;METHYL 4-BROMOCROTONATE, TECH., 85%;Methyl 4-bromocrotonate, pract., 85%;2-Butenoic acid, 4-bromo-, methyl ester;methyl 4-bromocrotonate (4-bromocrotonic acid methyl ester);Methyl-4-bromocrotonate(min.85%trans);Methyl-4-bromocrotonate, 95 % (min. 90 % trans);Methyl-4-bromocrotonate, 96 % (min. 97 % trans)
• CAS NO: 1117-71-1
• Molecular Formula: C₅H₇BrO₂
• Molecular Weight: 179.01
• EINECS: 214-251-0
• Product Categories: C2 to C5;Carbonyl Compounds;Esters
• Mol File: 1117-71-1.mol

Chemical Properties

• Boiling Point: 83-85 °C13 mm Hg(lit.)
• Flash Point: 197 °F
• Appearance: Clear yellow/Liquid
• Density: 1.522 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.358mmHg at 25°C
• Refractive Index: n20/D 1.501
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• BRN: 1745755
• CAS DataBase Reference: Methyl 4-bromocrotonate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-bromocrotonate(1117-71-1)
• EPA Substance Registry System: Methyl 4-bromocrotonate(1117-71-1)

Safety Data

• Hazard Codes: Xi,C
• Statements: 37/38-41-34-20/21/22
• Safety Statements: 26-39-45-36/37/39
• RIDADR: 3265
• WGK Germany: 3
• RTECS: GQ3120000
• F: 8-9
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1117-71-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-bromocrotonate is used as a synthetic intermediate for the development of irreversible inhibitors of EGFR and HER-2 tyrosine kinases. These inhibitors possess enhanced antitumor activities, making them essential in the creation of novel therapeutic agents for the treatment of various cancers.
Used in Chemical Synthesis:
As a synthetic intermediate, Methyl 4-bromocrotonate is employed in the synthesis of a wide range of chemical compounds. Its versatility in chemical reactions allows researchers and chemists to explore its potential in creating new molecules with specific applications across different industries.

InChI:InChI=1/C5H7BrO2/c1-8-5(7)3-2-4-6/h2-3H,4H2,1H3/b3-2-

Upstream product

• 67-56-1 methanol 
• 60-29-7 diethyl ether 
• 99848-36-9 Methyl 2-methoxycyclopropanecarboxylate 
• 124-41-4 sodium methylate 
• 56-23-5 tetrachloromethane 
• 623-43-8 crotonic acid methyl ester 
• 3699-18-1 N-bromoglutarimide 
• 623-43-8 methyl crotonate 
• 71-43-2 benzene 
• 5837-73-0 methyl 2-hydroxybut-3-enoate 
• 7789-60-8 phosphorus tribromide 
• 29576-13-4 methyl 4-hydroxy-2-butenoate 
• 3724-65-0 2-butenoic acid 
• 13991-36-1 4-bromocrotonic acid 

Downstream Products

• 90035-36-2 4-[oxy-(4-dimethylamino-phenyl)-imino]-trans-crotonic acid ethyl ester 
• 101723-21-1 (E)-methyl 5,5-diphenylpenta-2,4-dienoate 
• 38651-67-1 4-(1-hydroxy-cyclohexyl)-crotonic acid methyl ester 
• 56949-94-1 2-(α-hydroxy-benzyl)-but-3-enoic acid methyl ester 
• 103582-08-7 methyl (2E,4E)-5-(4-hydroxyphenyl)penta-2,4-dienoate 
• 17171-08-3 methyl (2E,4E)-5-((p-methoxy)phenyl)penta-2,4-dienoate 
• 121642-72-6 4-(1-hydroxy-4-methyl-cyclohexyl)-trans-crotonic acid methyl ester 
• 856184-72-0 2-(1-hydroxy-4-methyl-cyclohexyl)-but-3-enoic acid methyl ester 
• 121642-65-7 4-(1-hydroxy-2-methyl-cyclohexyl)-trans-crotonic acid methyl ester 
• 121642-64-6 2-(1-hydroxy-2-methyl-cyclohexyl)-but-3-enoic acid methyl ester 
• 107623-64-3 5t-(2-methoxy-phenyl)-penta-2t,4-dienoic acid methyl ester 
• 92356-73-5 5t-(4-dimethylamino-phenyl)-penta-2t,4-dienoic acid methyl ester 
• 100717-79-1 methyl (E)-2-(4-(dimethylamino)benzylidene)but-3-enoate 
• 114524-36-6 methyl γ-phenoxycrotonate 

Relevant articles and documents

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