- By accompanies two fluorine olefin preparing multi-substituted furan derivatives
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The invention relates to a method for preparation of a polysubstituted furan derivative, the method comprises the following main steps: in the presence of a copper salt and an oxyacid salt of an IA element in the element periodic table, gem-difluoroolefin
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Paragraph 0057; 0058; 0059; 0060; 0061; 0202; 0203-0206
(2017/07/26)
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- Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans
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The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.
- Huang, Yubing,Li, Xianwei,Yu, Yue,Zhu, Chuanle,Wu, Wanqing,Jiang, Huanfeng
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p. 5014 - 5020
(2016/07/06)
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- Copper-catalyzed coupling cyclization of gem -difluoroalkenes with activated methylene carbonyl compounds: Facile domino access to polysubstituted furans
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A novel and efficient CuI-catalyzed synthesis of 2,3,5-trisubstituted furans was developed via coupling cyclization of gem-difluoroalkenes with active methylene carbonyl compounds such as 1,3-dicarbonyl compounds, acetoacetonitrile, and phenylsulfonylacet
- Zhang, Xuxue,Dai, Wenpeng,Wu, Wei,Cao, Song
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supporting information
p. 2708 - 2711
(2015/06/16)
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