1020957-41-8

Basic information

• Product Name: 4-(cyclohexylamino)butanenitrile
• Synonyms: 4-(cyclohexylamino)butanenitrile
• CAS NO: 1020957-41-8
• Molecular Formula: C₁₀H₁₈N₂
• Molecular Weight: 166.27
• Mol File: 1020957-41-8.mol

Chemical Properties

• Boiling Point: 302.3±25.0 °C(Predicted)
• Appearance: /
• Density: 0.93±0.1 g/cm3(Predicted)
• PKA: 10.27±0.20(Predicted)
• CAS DataBase Reference: 4-(cyclohexylamino)butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(cyclohexylamino)butanenitrile(1020957-41-8)
• EPA Substance Registry System: 4-(cyclohexylamino)butanenitrile(1020957-41-8)

Safety Data

• Hazardous Substances Data: 1020957-41-8(Hazardous Substances Data)

Upstream product

• 77516-53-1 N-cyclohexyl-2-nitrobenzenesulfonamide 
• 108-91-8 cyclohexylamine 
• 1027379-53-8 cyano acrylate 

Downstream Products

• 79419-72-0 N-(4-aminobutyl)cyclohexylamine 

Relevant articles and documents

Chemical Synthesis and Biological Effect on Xylem Formation of Xylemin and Its Analogues

Xylemin (6) and its designed structural analogues 18–23, N-(4-aminobutyl)alkylamines, were synthesized by 2-nitrobenzenesulfonamide (Ns) strategy. Investigation of the improved synthesis of 20–23 resulted in the development of one-step synthesis of these analogues from the commercially available corresponding ketones. Biological assessment of the synthetic molecules elucidated that xylemin (6) and the analogue N-(4-aminobutyl)cyclopentylamine (21) promoted the expression level of thermospermine synthase ACAULIS5 (ACL5) and enhanced xylem formation. In addition, xylemin (6) was found to significantly promote lateral root formation, whereas xylemin analogues 18–23 including 21 did not. These results indicate that the analogue 21 has the potential as a novel inhibitor of thermospermine synthesis to work specifically in xylem differentiation.

Room temperature solvent free aza-Michael reactions over nano-cage mesoporous materials

An efficient highly acidic three dimensional mesoporous aluminosilicate nano-cage material Al-KIT5, exhibited excellent catalytic activity in solvent free room temperature aza-Michael reactions of amines with α,β- unsaturated carbonyl compounds to produce β-amino carbonyl compounds with 100% product selectivity in a short reaction time. The high acidity, 3D pores, and a huge space in the nano-cages materials make them attractive candidate for carrying out important organic reactions. The catalyst provide a simple, easy to handle method, and could be used to solve the problems of corrosion, toxicity, waste production, and a high cost that are being currently encountered by the conventional homogeneous catalysts.

Copper-Catalyzed Cyanoalkylation of Amines via C-C Bond Cleavage: An Approach for C(sp3)-N Bond Formations

The efficient copper-catalyzed cyanoalkylation of amines via C-C bond cleavage has been demonstrated. Distinctive features of this procedure involves mild conditions, broad range of nitrogen nucleophiles, high selectivity, and good functional group tolerance, thus providing a useful approach for the C(sp3)-N bond formations. Most importantly, this protocol is applicable to the late-stage functionalization of natural products, amino acid esters, and drugs. Mechanistic studies suggest that a radical intermediate was involved in this transformation.