102123-85-3 Usage
Uses
Used in Research Applications:
BOC-LEU-CHLOROMETHYLKETONE is used as a research tool for studying the structure, function, and mechanism of action of proteolytic enzymes. Its ability to inhibit enzyme activity makes it valuable in understanding the biological roles of these enzymes and their involvement in various diseases.
Used in Pharmaceutical Development:
In the pharmaceutical industry, BOC-LEU-CHLOROMETHYLKETONE is utilized as a lead compound in the development of potential therapeutic agents targeting proteases. Its inhibitory properties can be harnessed to create drugs that modulate protease activity, offering new treatment options for diseases where proteases play a significant role.
Used in Drug Design and Synthesis:
BOC-LEU-CHLOROMETHYLKETONE serves as a key component in the design and synthesis of novel protease inhibitors. Its unique structure allows for the creation of compounds with specific binding affinities and selectivity, which can be optimized for therapeutic use.
Used in Biochemical Assays and Screening:
BOC-LEU-CHLOROMETHYLKETONE is employed in biochemical assays and high-throughput screening processes to identify and characterize protease inhibitors. Its reactivity with proteolytic enzymes enables the rapid evaluation of potential drug candidates and the assessment of their inhibitory potency.
Used in Diagnostic Applications:
BOC-LEU-CHLOROMETHYLKETONE can be applied in diagnostic assays to detect and measure the activity of specific proteases. Its binding properties allow for the development of sensitive and specific tests that can aid in the diagnosis and monitoring of diseases associated with protease activity.
Check Digit Verification of cas no
The CAS Registry Mumber 102123-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,1,2 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 102123-85:
(8*1)+(7*0)+(6*2)+(5*1)+(4*2)+(3*3)+(2*8)+(1*5)=63
63 % 10 = 3
So 102123-85-3 is a valid CAS Registry Number.
102123-85-3Relevant articles and documents
Amino acids and peptides. XXXVI. Synthesis of enkephalin chloromethyl ketone and evaluation of its inhibitory activity against endopeptidase 22.19
Taguchi,Nishiyama,Camargo,Okada
, p. 2038 - 2039 (2007/10/02)
Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl was synthesized by the conventional solution method. During the course of acid hydrolysis (6N HCl, 110°C, 18h) of Boc-Phe-Leu-CH2Cl, side reaction occurred, resulting in low recovery of Phe residue on amino acid analysis. The inhibitory activity of the synthesized Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl against endopeptidase 22.19, an enzyme related to the metabolism of opioid peptides, was examined.
Synthesis and Reduction of α-Amino Ketones Derived from Leucine
Dufour, Marie-Noelle,Jouin, Patrick,Poncet, Joel,Pantaloni, Antoine,Castro, Bertrand
, p. 1895 - 1900 (2007/10/02)
New α-amino ketones (5) derived from leucine have been synthesized by reaction of organometallics on N-methoxy-N-methylamide (4).The stereoselectivity of reduction of the α-amino ketones (5) was studied.The stereochemistry of the resulting α-amino alcohol
