- Amino acids and peptides. XXXVI. Synthesis of enkephalin chloromethyl ketone and evaluation of its inhibitory activity against endopeptidase 22.19
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Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl was synthesized by the conventional solution method. During the course of acid hydrolysis (6N HCl, 110°C, 18h) of Boc-Phe-Leu-CH2Cl, side reaction occurred, resulting in low recovery of Phe residue on amino acid analysis. The inhibitory activity of the synthesized Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl against endopeptidase 22.19, an enzyme related to the metabolism of opioid peptides, was examined.
- Taguchi,Nishiyama,Camargo,Okada
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p. 2038 - 2039
(2007/10/02)
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- Synthesis and Reduction of α-Amino Ketones Derived from Leucine
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New α-amino ketones (5) derived from leucine have been synthesized by reaction of organometallics on N-methoxy-N-methylamide (4).The stereoselectivity of reduction of the α-amino ketones (5) was studied.The stereochemistry of the resulting α-amino alcohol
- Dufour, Marie-Noelle,Jouin, Patrick,Poncet, Joel,Pantaloni, Antoine,Castro, Bertrand
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p. 1895 - 1900
(2007/10/02)
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