77076-37-0

Upstream product

• 102123-85-3 (S)-1-chloro-2-oxo-3-(Boc-amino)-5-methylhexane 
• 75899-20-6 (C₅H₉O₂)(NHCHCOO)(CH₂C₃H₇)(CO₂C₂H₅) 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 54518-92-2 Leu-chloromethyl ketone hydrochloride 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 155650-93-4 3-Benzyl-6-isobutyl-5-methyl-1H-pyrazin-2-one 

Relevant academic research and scientific papers

Amino acids and peptides. XXXVI. Synthesis of enkephalin chloromethyl ketone and evaluation of its inhibitory activity against endopeptidase 22.19

Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl was synthesized by the conventional solution method. During the course of acid hydrolysis (6N HCl, 110°C, 18h) of Boc-Phe-Leu-CH2Cl, side reaction occurred, resulting in low recovery of Phe residue on amino acid analysis. The inhibitory activity of the synthesized Boc-Tyr-Gly-Gly-Phe-Leu-CH2Cl against endopeptidase 22.19, an enzyme related to the metabolism of opioid peptides, was examined.

Simple Approach Towards the Synthesis of 5-Methyl-2-hydroxypyrazine Derivatives from Dipeptidyl Chloromethyl Ketones

5-Methyl-2-hydroxypyrazine derivatives were easily synthesized by short reflux of dipeptidyl chloromethyl ketone hydrochlorides in MeOH.