1021443-92-4

Basic information

• Product Name: 2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE
• Synonyms: 2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE;2-NITRO-5-P-TOLYL-THIOPHEN-3-YLAMINE
• CAS NO: 1021443-92-4
• Molecular Formula: C₁₁H₁₀N₂O₂S
• Molecular Weight: 234.2743
• Mol File: 1021443-92-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE(1021443-92-4)
• EPA Substance Registry System: 2-NITRO-3-AMINO-5-P-TOLYLTHIOPHENE(1021443-92-4)

Safety Data

• Hazardous Substances Data: 1021443-92-4(Hazardous Substances Data)

Upstream product

• 943252-37-7 (Z)-3-chloro-3-(4-methylphenyl)-2-propenenitrile 
• 563-70-2 bromonitromethane 
• 106-49-0 p-toluidine 

Relevant articles and documents

2-Bromo-2-chloro-3-arylpropanenitriles as C-3 Synthons for the Synthesis of Functionalized 3-Aminothiophenes

2-Bromo-2-chloro-3-arylpropanenitriles can be prepared by Meerwein reaction from 2-chloroacrylonitrile and various aryldiazonium salts under copper(II) bromide catalysis. They proved to be stable compounds which form 2-chlorocinnnamonitriles upon treatment with bases. Reaction of the title compounds with substituted thioglycolates gave substituted 3-aminothiophenes which have not yet been accessible by other routes. Three-component reactions with the title compound, sodium sulfide and bromonitromethane, chloroacetonitrile, or ethyl 4-chloroacetoacetate gave 2-nitro- and 2-cyano-substituted 3-aminothiophenes, and thienopyridinediones in high yields and in one single step, respectively.

One-pot synthesis of substituted 3-amino-2-nitrothiophenes and selenophenes

In this work, we described an easy preparation of substituted 3-amino-2-nitrothiophenes and selenophenes. Substituted β-chloroacrylonitriles were reacted with sodium sulfide or sodium selenide and bromonitromethane to yield the expected compounds in a one-pot three-step procedure in good yields.