102269-68-1Relevant articles and documents
PROCEDURE FOR THE SYNTHESIS OF FLUORESCENT PROBES FOR METALS
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Page/Page column 26; 27, (2011/07/09)
A synthesis procedure is provided of a compound having general formula III, in which m and m' are selected, independently of each other, from a group consisting of : 1, 2, 3; the procedure comprises a synthetic step, during which a crown compound presenting the general formula I reacts with a derivative of a 8-hydroxy-quinoline (Der-H) in the presence of an aldehyde II.(I, II, III).
Microwave assisted synthesis of a small library of substituted N, N ′-Bis((8-hydroxy-7-quinolinyl)methyl)-1,10-diaza-18-crown-6 ethers
Farruggia, Giovanna,Iotti, Stefano,Lombardo, Marco,Marraccini, Chiara,Petruzziello, Diego,Prodi, Luca,Sgarzi, Massimo,Trombini, Claudio,Zaccheroni, Nelsi
supporting information; experimental part, p. 6275 - 6278 (2010/12/19)
Figure presented. N,N′-Bis-((8-hydroxy-7-quinolinyl)methyl)-1,10- diaza-18-crown-6 ether 1a and its analogue 1c are known as fluorescent sensors of magnesium in living cells. With the aim to investigate the effects of the substitution pattern on the photophysical properties of ligands 1 and their metal complexes, we developed an efficient microwaves enhanced one-pot Mannich reaction to double-armed diaza-crown ligands 1 carrying a variety of substituents. This new protocol is characterized by shorter reaction times, enhanced yields, and improved product purities with respect to the use of conventional conductive heating.
