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4053-45-6Relevant academic research and scientific papers
Facile route fabrication of nickel based mesoporous carbons with high catalytic performance towards 4-nitrophenol reduction
Yang, Ying,Ren, Yang,Sun, Chengjun,Hao, Shijie
, p. 2273 - 2280 (2014)
Novel nickel based mesoporous carbons are firstly in situ fabricated via pyrolysis of CTAB-chitosan-nickel supramolecular aggregates, which are pre-constructed by CTAB-directed self-assembly of 8-quinolinol modified chitosan and nickel acetate under basic conditions. This facile route fabrication method renders smart and homogeneously dispersed Ni nanoparticles (NPs) on the mesoporous carbonaceous framework without using any stabilizer and additional reductant, verified by high-energy X-ray diffraction, TEM, X-ray absorption fine structure, N2 adsorption/desorption and Raman spectroscopy. Moreover, it is found that the morphology of Ni NPs, the textural property of carbonaceous supports, and the corresponding catalytic performance towards 4-nitrophenol reduction vary with the pyrolysis temperature. It is suggested that the nickel based mesoporous carbon pyrolyzed at 750 °C (Ni/MC-750) simultaneously possessing uniform spherical Ni NPs (24.5 nm) and bottle-neck mesopores exhibits the largest activity factor of 20.9 s-1 g -1 of any nickel catalysts. the Partner Organisations 2014.
Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors
Xing, Jing,Zhang, Rukang,Jiang, Xiangrui,Hu, Tianwen,Wang, Xinjun,Qiao, Gang,Wang, Junjian,Yang, Fengling,Luo, Xiaomin,Chen, Kaixian,Shen, Jingshan,Luo, Cheng,Jiang, Hualiang,Zheng, Mingyue
, p. 281 - 294 (2019)
Bromodomain-containing protein 4 (BRD4), an epigenetic reader of acetyl lysine, has emerged as a promising therapeutic target for many diseases including cancer, inflammation and heart failure. Our previous study reported that nitroxoline, an FDA approved antibiotic, showed potential BRD4 inhibitory activity and antiproliferation activity against leukemia cell lines. In this study, we further explored the structure-activity relationship (SAR) around nitroxoline and employed our previously developed machine learning based activity scoring function BRD4LGR for further analysis. To improve the cellular level activity, physico-chemical properties were optimized using computational approaches. Then the candidates were tested for their ADME/T profiles. Finally, based on this rational hit-to-lead optimization strategy, 3 drug-like BRD4 inhibitors were obtained, with different profiles on cell line selectivity for multiple myeloma, leukemia and triple negative breast cancer. Further mechanism study showed these compounds could down-regulate c-Myc to inhibit cancer cell growth. This work illustrates the application of multiple computer-aided drug design techniques in a hit-to-lead optimization scenario, and provides novel potent BRD4 inhibitors with different phenotype propensities for future cancer treatment.
Experimental investigation on the corrosion inhibition of carbon steel by 5-(chloromethyl)-8-quinolinol hydrochloride in hydrochloric acid solution
El Faydy,Galai,El Assyry,Tazouti,Touir,Lakhrissi,Ebn Touhami,Zarrouk
, p. 396 - 404 (2016)
5-(chloromethyl)-8-quinolinol hydrochloride (Cl-QH) was synthesized and characterized. Thus, its inhibition effect on XC38 steel corrosion in 1 M HCl medium was investigated using weight loss and electrochemical measurements. Polarization measurements indicated that, the studied compound acts as a mixed type inhibitor, the inhibition efficiency depends on its concentration and reaches 97% at 10- 3 M. Electrochemical impedance spectroscopy showed that the Cl-QH acts by the formation of a protective film at the metallic surface. The adsorption of the studied compound followed the Langmuir isotherm. So, scanning electronic microscopy (SEM) confirms the performance of Cl-QH against corrosion. In addition, quantum chemical calculations using DFT at the B3LYP/6-31G?level of theory was further used to calculate and discussed some electronic properties of the studied molecule. The theoretical and experimental results are in good agreement.
Synthesis and photophysics of novel 8-hydroxyquinoline aluminum metal dye with hole transfer groups
Wang, Xiaoju,Feng, Liheng,Chen, Zhaobin
, p. 1433 - 1437 (2008)
A novel luminescent dye metal complex, (CZHQ)3Al, with 8-hydroxyquinoline aluminum and hole-transporting carbazole units was designed and synthesized. The (CZHQ)3Al optical properties were carefully investigated by UV-vis absorption and fluorescence spectra in diluent solution. The results showed that the luminescent quantum yield of (CZHQ)3Al was 0.62 in DMSO and it emitted red-light with the band gap of 2.89 eV estimated from the onset absorption. In addition, the light-emission of (CZHQ)3Al can be quenched by electron acceptor (dimethylterephalate), where the process followed the Stern-Volmer equation. However, the fluorescent intensities of (CZHQ)3Al were slowly increased with the addition of electron donor (N,N-dimethylaniline). Furthermore, the molecular interactions of (CZHQ)3Al with fullerene (C60) and carbon nanotubes (CNTs) were also respectively investigated, which indicated the metal dye can be used as new fluorescent probe.
Coordination polymers of N, N'-di-(8-Hydroxyquinolinolyl- 5-methyl)-N, N-diethyl-1, 3-propane diamine (QEPD)
Patel, Asha D.,Patel, Rignesh S.,Patel, Ganpat R.
, p. 1023 - 1028 (2010)
Coordination polymers containing a novel bis(oxine) bidentate ligand, namely N,N'-di(8-hydroxyquinolinolyl-5-methyl)-N,N'-diethyl-1,3- propane diamine (QEPD) have been prepared with the metal ions Zn(II), Cu(II), Ni(II), Co(II) and Mn(II). The novel bis-(bidentate) ligand was synthesized by condensation of 5-chloromethyl-8-hydroxyquinoline hydrochloride with N,N'-diethyl-1,2- propane diamine in the presence of a base catalyses. All of these coordination polymers and the parent ligand were characterized by elemental analyses, IR spectral and diffuse reflectance spectral studies. The thermal stability and number- average molecular weights (Mn) of all of the coordination polymers were determined by thermogravimetric analyses and non-aqueous conductometric titrations, respectively. In addition, all of the coordination polymers have been characterized by their magnetic susceptibilities.
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease
Wang, Zhiren,Hu, Jinhui,Yang, Xiaoping,Feng, Xing,Li, Xingshu,Huang, Ling,Chan, Albert S. C.
, p. 1871 - 1894 (2018)
A novel series of quinoline-indole derivatives were synthesized and evaluated as multitarget-directed ligands for the treatment of Alzheimer's disease (AD). Biological evaluation revealed that the derivatives had multifunctional profiles including antioxidant effects, blood-brain barrier (BBB) penetration, biometal chelation, Aβ aggregation modulation, neurotrophic and neuroprotective properties. Moreover, several representative target derivatives demonstrated hippocampal cell proliferation in living adult mice by intracerebroventricular (icv) injection or oral administration. Further drug-like property analysis demonstrated that the optimized compound, 8d (WI-1758), had liver microsomal metabolic stability, was well tolerated (>2000 mg/kg), and had a rational pharmacokinetic profile, as well as an oral bioavailability of 14.1% and a positive log BB (-0.19) to cross the BBB in vivo. Pharmacodynamics studies demonstrated that chronic oral administration of 8d·HCl substantially ameliorated the cognitive and spatial memory deficits in APP/PS1 AD mice and noticeably reduced overall cerebral β-amyloid deposits.
Synthesis and characterization of novel Cu (II) and Zn (II) complexes of 5-{[(2-Hydroxyethyl) sulfanyl] methyl}-8-hydroxyquinoline as effective acid corrosion inhibitor by experimental and computational testings
Abousalem, Ashraf S.,Benhiba, F.,Ebn Touhami, M.,Galai, M.,Jama, C.,Lai, Chin-Hung,Lakhrissi, B.,Ouakki, M.,Rbaa, M.,Warad, I.,Zarrouk, A.
, (2020)
Two new complexes were synthesized, characterized and tested as inhibitors for mild steel corrosion in 1.0 M HCl. The anticorrosive effect has been studied using the potentiodynamic polarization (PDP) and impedance spectroscopy (EIS). The inhibitory efficiency increases with increasing concentration to reach 96.0percent for Q-Cu and 94.6percent for Q-Zn at 10?3 M. The two inhibitors are mixed type and follows the Langmuir isotherm adsorption. The surface of the mild steel has been examined by SEM/EDS and the corrosive solution by ICP-OES. DFT calculations and molecular dynamic simulation (MD) show a good correlation with the experimental results for both complexes.
Spectroscopic, photophysical, solution thermodynamics and computational study of europium and terbium complexes with a flexible quinolinol-based symmetric tripodal chelator
Akbar, Rifat,Baral, Minati,Kanungo, B. K.
, (2021)
Coordination behaviour and photonic properties of a flexible tripodal multidentate ligand, 5,5′,5′'-(Cyclohexane-1,3,5-triyltris(oxy))tris(methylene)triquinolin-8-ol (CYTOM5OX), with Eu and Tb ions were explored through potentiometric, UV-visible and fluorescence spectrophotometric methods. The interaction of tripod towards the lanthanides has been examined for thermodynamic equilibrium, photophysical behavior, and time-resolved luminescence measurements. Besides, a theoretically empirical method followed by quantum mechanical treatment of these chelates has also been summarized. A noticeable change in the electronic spectra of these complexes disclose CYTOM5OX as a pH-sensitive optical sensor for lanthanides detection; also, a strong green fluorescence allows simultaneous sensing in the visible region in a competitive medium. The intense fluorescence intermittently gets quenched under acidic and basic conditions due to photoinduced intramolecular electron transfer from the excited 8-hydroxyquinoline (8-HQ) moiety to the metal ion. The thermodynamically stable Ln3+ complexes in aqueous solution show stability constants in the range log β110 = 33–35 and pLn3+ in the range of 21–22. The hydration number that was predicted by the coordination scan was substantiated by lifetime measurements reveal presence of coordinated water molecules in Eu(CYTOM5OX) and Tb(CYTOM5OX) complexes. Theoretical spectra were also calculated by ZINDO/s methodology at single excitations (CIS) level on PM7 as sparkle energy-minimized geometries.
Design and Synthesis of Nanosensor Based on CdSe Quantum Dots Functionalized with 8-Hydroxyquinoline: a Fluorescent Sensor for Detection of Al3+ in Aqueous Solution
Eftekhari-Sis, Bagher,Samadneshan, Khadijeh,Vahdati-Khajeh, Saleh
, p. 767 - 774 (2018)
A novel nanosensor based on CdSe quantum dots (QDs) capped with 8-hydroxyqunoline (HQ) was developed for Al3+ ions determination in aqueous solutions. The method is based on the fluorescence enhancement of the HQ functionalized QDs in the presence of Al3+ ions, due to the strong interaction between Al3+ and HQ. Prepared nanosensor exhibited an acceptable selectivity and sensitivity for Al3+ ions in the presence of other metal ions. Plot of Log(I/I0) against Log[Al3+] shows a good linearity in the range of 0.02–3.0?mM, and the method could be used for detection of Al3+ ions concentration in aqueous solutions.
Sample synthesis, characterization, experimental and theoretical study of the inhibitory power of new 8-hydroxyquinoline derivatives for mild steel in 1.0 M HCl
Abousalem, Ashraf S.,Benhiba, F.,Galai, M.,Lakhrissi, B.,Oudda, H.,Rbaa, M.,Rouifi, Z.,Warad, I.,Zarrouk, A.
, (2020)
Some new compounds which are derived from 8-hydroxyquinoline were both prepared and characterized by IR, NMR spectroscopy and elemental analysis. After the successful synthesis, we tested these products as corrosion inhibitors of mild steel (MS) in 1.0 M HCl at 298 K ± 1. The anticorrosive property was achieved by electrochemical and theoretical methods such as potentiodynamic polarization (PDP), the spectroscopy impedance (EIS), density functional theory (DFT) calculations and the Monte Carlo simulation (MC). The experimental and theoretical results obtained show that these products have an excellent anticorrosive property for the MS. The thermodynamic parameters show that all the compounds adsorb to the metal surface by chemical bonds according to the Langmuir adsorption isotherm. The surface morphology was investigated using scanning electron spectroscopy (SEM) coupled with energy dispersive spectroscopy (EDS) and the FT-IR analysis. The gravimetric solutions after 6 h of immersion were analyzed by the UV–Visible spectrometry.
