- VANCOMYCIN DERIVATIVE, AND PREPARATION METHOD AND APPLICATION THEREOF
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The present invention provides a vancomycin derivative, and a preparation method and an application thereof. The vancomycin derivative of the present invention is obtained by introducing a glycerate moiety between a vancomycin derivative and a liposoluble
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Paragraph 0220; 0222-0223
(2016/08/17)
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- Design and synthesis of new vancomycin derivatives
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A set of vancomycin derivatives with lipid chain attached via a glyceric acid linker was designed and synthesized. A concise synthesis towards these derivatives was developed and the IC50s of these new lipoglycopeptides were tested. Some of them showed very potent activity against both vancomycin sensitive and resistant strains.
- Gu, Wen,Chen, Bei,Ge, Min
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p. 2305 - 2308
(2014/05/20)
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- Reaction of methyl diazoacetate with aldehydes, amines, thiols, alcohols and acids over transition metal-exchanged clays
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Metal-exchanged clays (M = Rh and Cu) catalyze effectively the reaction of methyl diazoacetate with various aldehydes, affording the corresponding β-keto esters in high yields. They have also been effective in the decomposition of methyl diazoacetate to form metallocarbenes which, in turn, successfully insert into X-H (X = N, O, S, CO2) bonds of a variety of amines, aldehydes, thiols and acids, thereby producing the corresponding esters. The Royal Society of Chemistry 1999.
- Phukan, Prodeep,Mohan, Jakkam Madan,Sudalai, Arumugam
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p. 3685 - 3689
(2007/10/03)
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