- Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N- (thiazole-2-yl)acetamide derivatives and their anticancer activities
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In this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N- (thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with some 2-chloro-N-(thiazol-2-yl)acetamide compou
- Duran, Murat,Demirayak, Seref
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p. 4110 - 4124
(2013/09/02)
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- Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
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In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl) thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds.
- Yurttas, Leyla,Duran, Murat,Demirayak, Seref,Gencer, Huelya Karaca,Tunali, Yagmur
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supporting information
p. 6764 - 6768
(2014/01/06)
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- 1-Arylaminoimidazole-2-thiones as intermediates in the synthesis of imidazo[2,1-b][1,3,4]thiadiazines
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The synthesis of the hitherto unknown imidazo[2,1-b][1,3,4]thiadiazines 7 in good to very good yields (up to 77%) by using suitable imidazole-2-thione precursors 1 has been described, while S-vinylimidazoles 8 and 9 were isolated as by-products. Moreover, the reactivity of the three possible reaction sites of the starting thiones 1 was initially examined by methylation experiments, whereupon the enhanced reactivity of sulfur was proven by the isolation of the methylated derivatives 3 and 4. By prolonged methylation the imidazolinone 6 is finally formed. Theoretical calculations support the experimental results of alkylation products.
- Neochoritis, Constantinos,Tsoleridis, Constantinos A.,Stephanidou-Stephanatou, Julia
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p. 3527 - 3533
(2008/09/21)
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