1022903-95-2

Upstream product

• 333-20-0 potassium thioacyanate 
• 4091-39-8 3-chloro-2-butanone 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 1435872-36-8 (2Z)-5-[[(1E,2E)-2-[2,2-bis(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-3-(4-chlorophenyl)-2-(tert-butylimino)-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-34-6 (2Z)-5-[[(1E,2E)-2-[2,2-bis(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-3-(4-chlorophenyl)-2-(cyclohexylimino)-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-46-0 (2Z)-5-[[(1E,2E)-2-[2,2-bis[(1-methylethoxy)carbonyl]hydrazono]-1-methylpropylidene]amino]-2-(cyclohexylimino)-3-(4-chlorophenyl)-2,3-dihydro-1,3,4-thiadiazole 
• 1435872-21-1 3-(4-chlorophenyl)-2,3-dihydro-2-(tert-butylimino)-5,6-dimethyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1435872-19-7 3-(4-chlorophenyl)-2-cyclohexylimino-2,3-dihydro-5,6-dimethyl-imidazo[2,1-b][1,3,4]thiadiazole 
• 1435872-52-8 (2Z)-3-(4-chlorophenyl)-2-(cyclohexylimino)-5-[[(1E,2E)-2-[2-(ethoxycarbonyl)hydrazono]-1-methylpropylidene]amino]-2,3-dihydro-1,3,4-thiadiazole 
• 1418010-88-4 2-[1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio]-N-(thiazol-2-yl)acetamide 
• 1418010-89-5 2-[1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio]-N-(4-methylthiazol-2-yl)acetamide 
• 1418010-91-9 ethyl 2-[2-(1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio)acetamido]thiazole-4-carboxylate 
• 1418010-92-0 2-[1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio]-N-(4-phenylthiazol-2-yl)acetamide 
• 1418010-93-1 2-[1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio]-N-[4-(4-methoxyphenyl)thiazol-2-yl]acetamide 
• 1418010-94-2 N-[4-(4-chlorophenyl)thiazol-2-yl]-2-[1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio]acetamide 
• 1418010-95-3 2-[1-(4-chlorophenylamino)-4,5-dimethyl-1H-imidazol-2-ylthio]-N-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide 
• 1207379-19-8 dimethyl 2-({1-[(4-chlorophenyl)amino]-4,5-dimethyl-1H-imidazol-2-yl}thio)but-2-enedioate 

Relevant academic research and scientific papers

Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N- (thiazole-2-yl)acetamide derivatives and their anticancer activities

In this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N- (thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with some 2-chloro-N-(thiazol-2-yl)acetamide compou

Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives

In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl) thio]-1-(aryl)ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the most effective compounds was established by performing Brine-Shrimp lethality assay. Antifungal activity of the compounds was found to be higher than antibacterial and anticancer activities of the compounds.

1-Arylaminoimidazole-2-thiones as intermediates in the synthesis of imidazo[2,1-b][1,3,4]thiadiazines

The synthesis of the hitherto unknown imidazo[2,1-b][1,3,4]thiadiazines 7 in good to very good yields (up to 77%) by using suitable imidazole-2-thione precursors 1 has been described, while S-vinylimidazoles 8 and 9 were isolated as by-products. Moreover, the reactivity of the three possible reaction sites of the starting thiones 1 was initially examined by methylation experiments, whereupon the enhanced reactivity of sulfur was proven by the isolation of the methylated derivatives 3 and 4. By prolonged methylation the imidazolinone 6 is finally formed. Theoretical calculations support the experimental results of alkylation products.