cas 10241-97-1, 5-METHYLINDOLE-2-CARBOXYLIC ACID | Articles data ｜lookchem

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10241-97-1

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Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a
The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.
Rosauer, Keith G.,Ogawa, Anthony K.,Willoughby, Chris A.,Ellsworth, Kenneth P.,Geissler, Wayne M.,Myers, Robert W.,Deng, Qiaolin,Chapman, Kevin T.,Harris, Georgianna,Moller, David E.
p. 4385 - 4388
(2007/10/03)

INDOLOYLGUANIDINE DERIVATIVES
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(2008/06/13)

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Chemical Properties

Appearance/Colour :light brown powder
Melting Point: 236-238ºC
Boiling Point: 421.2 ºC at 760 mmHg
Flash Point:208.5 ºC
Density: 1.34 g/cm³
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Vapor Pressure: 7.58E-08mmHg at 25°C
Refractive Index: 1.696
PKA: 4.48±0.30(Predicted)
BRN: 144055
PSA: 53.09000
LogP: 2.17450

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