1026-05-7

Basic information

• Product Name: (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE
• Synonyms: AKOS BBS-00005674;(2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE;ASISCHEM N44996;N-(2-METHYL-1,2,3,4-TETRAHYDRO-4-QUINOLINYL)-N-PHENYLAMINE;2-Methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-aMine
• CAS NO: 1026-05-7
• Molecular Formula: C₁₆H₁₈N₂
• Molecular Weight: 238.33
• Mol File: 1026-05-7.mol

Chemical Properties

• Melting Point: 126 °C
• Boiling Point: 400.4±44.0 °C(Predicted)
• Appearance: /
• Density: 1.097±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.16±0.60(Predicted)
• CAS DataBase Reference: (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE(1026-05-7)
• EPA Substance Registry System: (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE(1026-05-7)

Safety Data

• Hazardous Substances Data: 1026-05-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its structural features and potential biological activities make it a valuable component in the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE is utilized as a building block for the construction of more complex molecules with potential therapeutic properties. Its unique structure allows for the design and synthesis of novel compounds with improved pharmacological profiles.
Used in Drug Discovery:
(2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE plays a significant role in drug discovery, where it is employed as a starting material or a scaffold for the development of new chemical entities with potential therapeutic applications. Its versatility in chemical modifications and its ability to interact with biological targets make it a promising candidate for the identification of novel drug candidates.
Used in Organic Synthesis:
In organic synthesis, (2-METHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-4-YL)-PHENYL-AMINE serves as a versatile building block for the synthesis of a wide range of organic compounds. Its reactivity and functional group compatibility enable the preparation of diverse molecular structures with potential applications in various industries, including materials science, agrochemicals, and specialty chemicals.

Upstream product

• 75-07-0 acetaldehyde 
• 62-53-3 aniline 
• 74-86-2 acetylene 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 2235-00-9 vinylcaprolactam 
• 3195-78-6 N-vinyl-N-methylacetamide 
• 5202-78-8 acetylaminoethylene 
• 13162-05-5 n-vinylformamide 
• 109-92-2 ethyl vinyl ether 
• 111-34-2 -butyl vinyl ether 
• 1484-13-5 9-vinyl-9H-carbazole 
• 709-80-8 methyl N-(2, 6-dimethylphenyl)alaninate 
• 15727-49-8 N-Phenylalanin 
• 103-69-5 N-ethyl-N-phenylamine 

Downstream Products

• 857-45-4 (+/-)-4t-anilino-1-benzoyl-2r-methyl-1,2,3,4-tetrahydro-quinoline 
• 13125-50-3 (+/-)-N-(1-acetyl-2c-methyl-1,2,3,4-tetrahydro-[4r]quinolyl)-N-phenyl-acetamide 
• 857-45-4 (+/-)-4c-anilino-1-benzoyl-2r-methyl-1,2,3,4-tetrahydro-quinoline 
• 91-63-4 2-methylquinoline 
• 303226-75-7 (4-Anilino-2-methyl-3,4-dihydro-1(2H)-quinolinyl)(4-chlorophenyl)methanone 
• 300690-21-5 cis-(4-Anilino-2-methyl-3,4-dihydro-1(2H)-quinolinyl)(thien-2-yl)methanone 
• 103-69-5 N-ethyl-N-phenylamine 
• 62-53-3 aniline 
• 1026-05-7 trans-2-methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine 
• 1026-05-7 cis-2-methyl-N-phenyl-1,2,3,4-tetrahydroquinolin-4-amine 

Relevant articles and documents

Facile synthesis of 2-methylquinolines from anilines on mesoporous N-doped TiO2 under UV and visible light

Nitrogen-doped TiO2 was synthesized by a simple wet method using a nitrogen precursor hydrazine hydrate and nano TiO2. This photocatalyst was characterized by X-ray diffraction, highresolution transmission electron microscopy, diffused reflectance spectra, photoluminescence, and X-ray photoelectron spectroscopy. XPS analysis indicates the incorporation of anionic nitrogen in TiO2 lattice as O-Ti-N linkage. N2 adsorption-desorpion isotherm indicates the mesoporous nature of N-TiO2 with the surface area 130.0 m2/g. Sizes of N-TiO2 particles are found to be in the range of 5-30 nm by HRTEM images. DRS spectra reveal the extended absorption to the visible range. N-TiO2 is found to be more efficient than Ag-TiO2, Au-TiO2, and Pt-TiO2 in quinaldine synthesis under visible light. Copyright Taylor & Francis Group, LLC.

Synthesis and SAR of cis-1-Benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems

A library of 35 cis-1-benzoyl-2-methyl-4-(phenylamino)-1,2,3,4-tetrahydroquinolines was prepared. The compounds bore various substitutuents on the benzoyl ring, at the 4-position of the phenylamino ring and at the 6-position of the tetrahydroquinoline rin

Radical cation salts induced domino reaction of anilines with enol ethers: Synthesis of 1,2,3,4-tetrahydroquinoline derivatives

A domino reaction of anilines with cyclic and acyclic enol ethers induced by catalytic amounts of TBPA?+ (5 mol%) was investigated and a series of 2,4-disubstituted-1,2,3,4-tetrahydroquinolines were synthesized. Different from cyclic enol ethers, when acyclic enol ethers were used in the reaction, they serve as surrogates of acetaldehyde, producing a series of 2-methyl-4-anilino-1,2,3,4-tetrahydroquinolines. A single electron transfer mechanism was proposed to rationalize the products formation.

Photocatalytic Synthesis of Quinolines via Povarov Reaction under Oxidant-Free Conditions

We describe here an approach for synthesizing quinolines either from N-alkyl anilines or from anilines and aldehydes. A dual-catalyst system consisting of a photocatalyst and a proton reduction cocatalyst is employed. Without the use of any sacrificial ox

Method for synthesizing 1,2,3,4-tetrahydroquinoline compounds in mode that decarboxylation of amino acid is catalyzed by visible light

The invention relates to a method for synthesizing 1,2,3,4-tetrahydroquinoline compounds in the mode that decarboxylation of amino acid is catalyzed by visible light. The method is characterized in that in an air atmosphere, the N-phenyl amino acidic compounds shown in the formula I, an organic photocatalyst DPZ and 4-molecular sieve are dissolved in an organic solvent, stirred and reacted for atleast 5 hours at the temperature of 20-30 DEG C under the irradiation of the visible light, separation and purification are conducted, and then the tetrahydroquinoline compounds shown in the formula II are obtained, wherein in the formula I and the formula II (the formulas are shown in the description), R is representative for any one of hydrogen, halogen, alkyl, phenyl and alkoxy, R1 is representative for any one of hydrogen, methyl, n-propyl and phenyl, alkyl is representative for methyl or ethyl or normal-butyl or benzyl, and aryl is representative for substituted phenyl or 4-tert-butyl phenyl. According to the method, substrates are simple, reaction conditions are mild, the usage amount of the catalyst is low, the yield is high, and no metal participates in a reaction.

Method for synthesizing quinoline compounds in mode that oxidative dehydrogenation of tetrahydroquinoline compounds is synergistically catalyzed by visible light

The invention relates to a method for synthesizing quinoline compounds in the mode that oxidative dehydrogenation of tetrahydroquinoline compounds is synergistically catalyzed by visible light. The method comprises the specific steps that in an air atmosphere, the multi-substituted tetrahydroquinoline compounds shown in the formula I, an organic photocatalyst DPZ and an auxiliary catalyst Cl4-NHPIare dissolved into an organic solvent, stirred and reacted for at least 2 hours at the temperature of 20-30 DEG C under the irradiation of the visible light, separation and purification are conducted, and the quinoline compounds shown in the formula II are obtained, wherein in the formula I and the formula II (the formulas are shown in the description), R is representative for any one of hydrogen, halogen, alkyl, phenyl and alkoxy, R1 is representative for any one of hydrogen, methyl, n-propyl and phenyl, alkyl is representative for methyl or ethyl or normal-butyl or benzyl, and aryl is representative for substituted phenyl. According to the method, reaction conditions are mild, the method is environmentally friendly, the usage amount of the catalyst is low, the product conversion ratio is high, the selectivity is good and no metal participates in a reaction.

Sequential Photoredox Catalysis for Cascade Aerobic Decarboxylative Povarov and Oxidative Dehydrogenation Reactions of N-Aryl α-Amino Acids

A visible-light-driven sequential photoredox catalysis to allow N-aryl α-amino acids to experience efficient cascade aerobic decarboxylative Povarov and oxidative dehydrogenation (ODH) reactions is described. With a dicyanopyrazine-derived chromophore (DP

COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR

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Efficient bromination of polyaniline base to poly(2-bromoaniline)-bromide salt and its application as a recyclable catalyst for the synthesis of 2-methyl-4-anilino-1,2,3,4-tetrahydroquinolines

Efficient bromination of polyaniline base to poly(2-bromoaniline)-bromide is successfully carried out using bromodimethylsulfonium bromide. Poly(2-bromoaniline)-bromide salt was obtained in a dry amorphous nature, having high conductivity (2.5 S/cm) with

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