Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones
A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed.
Sui, Zhihua,Nguyen, Van N.,Altom, Jason,Fernandez, Jeffrey,Hilliard, Jamese J.,Bernstein, Jeffrey I.,Barrett, John F.,Ohemeng, Kwasi A
p. 381 - 387
(2007/10/03)
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