1027581-61-8

Basic information

• Product Name: Tri(t-butoxycarbonylethoxymethyl) ethanol
• Synonyms: Tri(t-butoxycarbonylethoxymethyl) ethanol
• CAS NO: 1027581-61-8
• Molecular Formula: C₂₆H₄₈O₁₀
• Molecular Weight: 520.65332
• Mol File: 1027581-61-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tri(t-butoxycarbonylethoxymethyl) ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: Tri(t-butoxycarbonylethoxymethyl) ethanol(1027581-61-8)
• EPA Substance Registry System: Tri(t-butoxycarbonylethoxymethyl) ethanol(1027581-61-8)

Safety Data

• Hazardous Substances Data: 1027581-61-8(Hazardous Substances Data)

Usage

Uses

Used in X-ray Imaging:
Tri(t-butoxycarbonylethoxymethyl) ethanol is used as a reactant in the synthesis of trinuclear tungsten(IV) oxo cluster complexes. These complexes are employed in x-ray imaging, providing a valuable tool for medical and diagnostic applications.
Used in Chemical Synthesis:
As a branched PEG linker, Tri(t-butoxycarbonylethoxymethyl) ethanol can be utilized in various chemical synthesis processes. Its hydroxyl group allows for further derivatization, making it a useful building block for the creation of more complex molecules and compounds.
Used in Pharmaceutical and Biochemical Research:
The ability to deprotect the t-butyl groups under acidic conditions makes Tri(t-butoxycarbonylethoxymethyl) ethanol a valuable asset in pharmaceutical and biochemical research. It can be used to create new drug candidates or to study the interactions of molecules with biological systems.
Used in Material Science:
Tri(t-butoxycarbonylethoxymethyl) ethanol's unique structure and functional groups make it a potential candidate for use in material science. It can be incorporated into the development of new materials with specific properties, such as improved stability or reactivity.

Upstream product

• 115-77-5 Pentaerythritol 
• 1663-39-4 tert-Butyl acrylate 

Downstream Products

• 175724-35-3 4-Isothiocyanato-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester 
• 175724-34-2 4-Amino-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester 
• 175724-33-1 4-Nitro-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester 

Relevant articles and documents

BIS TRIDENTATE W3O2 CLUSTERS FOR X-RAY IMAGING

The present invention describes a new class of highly stable W3O2 Clusters, a method for their preparation, their use as X-ray contrast agents and the intermediates tri- or tetracarboxylic acids as desired tridentate ligand resources.

Bis Tridentate W3O2 Clusters for X-Ray imaging

The present invention describes a new class of highly stable W3O2 Clusters, a method for their preparation, their use as X-ray contrast agents and the intermediates tri- or tetracarboxylic acids as desired tridentate ligand resources.

Synthesis of branched cores by poly-O-alkylation reaction under phase transfer conditions. A systematic study

In the present paper is described a systematic study of poly-O-alkylation reactions of pentaerythritol (PE) and 1,1,1-tris(hydroxymethyl)ethane (TME) by 1,4 Michael addition, under phase transfer catalysis (PTC), considering the effect of: (1) the organophilicity of PTC (three different catalysts were tested), (2) PTC concentration (from catalytic to equimolar conditions), and (3) the regime of addition of reactants coexisting in the aqueous phase of the heterogeneous reaction system. The less organophilic transfer agent showed the best performance on these reactions. In our case, benzyltriethylammonium chloride (TEBAC) gathers the best features. The presence of NaOH as base, promotes the interfacial mechanism and not the bulk one. Out of the optimal range of concentration of NaOH (35-40%), competition between nucleophiles can occur, due to the saturation of the medium. Regarding the regime of addition of reactants, the scenario where NaOH and TEBAC are less time in contact, favors the formation of the desired products. Finally, the deprotection of tert-butyl groups of the poly-O-alkylated compounds is described, to get branched cores with terminal carboxylic acid groups in good yields (90-94%). Spectroscopic properties, such as IR, 1H and 13C NMR, of the synthesized compounds are also described.

New polypodal polycarboxylic ligands - Complexation of rare-earth ions in aqueous solution

The complexation ability of new polypodal carboxylic ligands prepared from 2,2-bis(hydroxymethyl)-1-alkanols was investigated in aqueous solution with Y3+ and various lanthanide ions (La3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+). The values of the stability constants for ML complexes are of the order of 104 for the hexadentate trioxypropionates, 107 for the hexadentate trioxyacetates and 1014 for the nonadentate triaminohexaacetates. In these systems, the nitrogens of the amino groups seem to be better chelating atoms than the oxygens of the ether groups. The hydration numbers of dysprosium(III) complexes have been determined from the DyIII-induced 17O NMR water shifts.

Polyalkylation of primary polyols by 1,4-addition to tert-butyl acrylate and acrylonitrile

The very hydrophilic primary polyols pentaerythritol (PE), 1,1,1-tris(hydroxymethyl)ethane and tris(hydroxymethyl)aminomethane (TRIS), can be polyetherified in satisfactory yield by 1,4-addition to tert-butyl acrylate using phase-transfer catalysis. Polycyanoethylation of these polyols can also be accomplished with acrylonitrile. Preliminary results of chelation between some polyether-acids with samarium(III) are presented.