Tri(t-butoxycarbonylethoxymethyl) ethanol

Base Information

• Chemical Name: Tri(t-butoxycarbonylethoxymethyl) ethanol
• CAS No.: 1027581-61-8
• Molecular Formula: C₂₆H₄₈O₁₀
• Molecular Weight: 520.661
• Mol file: 1027581-61-8.mol

Synonyms:tert-butyl 3-[3-(3-tert-butoxy-3-oxopropoxy)-2-[(3-tert-butoxy-3-oxopropoxy)methyl]-2-(hydroxymethyl)propoxy]propanoate

Chemical Property of Tri(t-butoxycarbonylethoxymethyl) ethanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Tri(t-butoxycarbonylethoxymethyl)Ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Tri(t-butoxycarbonylethoxymethyl) ethanol is a branched PEG linker with a hydroxyl group and three t-butyl protecting groups. The hydroxyl group can react to further derivatize the compound. The t-butyl groups can be deprotected under acidic conditions.
• Uses: Tri(t-butoxycarbonylethoxymethyl) Ethanol is used as a reactant in the synthesis of trinuclear tungsten(IV) oxo cluster complexes for x-ray imaging.

Technology Process of Tri(t-butoxycarbonylethoxymethyl) ethanol

There total 2 articles about Tri(t-butoxycarbonylethoxymethyl) ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

Pentaerythritol (115-77-5) + tert-Butyl acrylate (1663-39-4,25232-27-3) → di-tert-butyl 3,3'-{[2,2-bis(hydroxymethyl)propane-1,3-diyl]bis(oxy)}dipropanoate (1427320-40-8) + 3-(2-tert-butoxycarbonylethoxy)propionic acid tert-butyl ester (1427320-41-9) + tert-butyl 3-[3-(3-tert-butoxy-3-oxopropoxy)-2-[(3-tert-butoxy-3-oxopropoxy)methyl]-2-(hydroxymethyl)propoxy]propanoate (1027581-61-8) + 3-[3-(2-tert-butoxycarbonylethoxy)-2,2-bis-(2-tert-butoxycarbonylethoxymethyl)propoxy]propionic acid tert-butyl ester (175724-29-5)

Guidance literature:

Pentaerythritol; With sodium hydroxide; In water; at 20 ℃; for 1h; Inert atmosphere; Darkness;

tert-Butyl acrylate; With N-benzyl-N,N,N-triethylammonium chloride; In water; at 20 ℃; for 18h; Reagent/catalyst; Concentration; Inert atmosphere; Darkness; Cooling with ice;

DOI:10.1016/j.molstruc.2013.01.034

Reference yield: 38.0%

Pentaerythritol (115-77-5) + tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl 3-[3-(3-tert-butoxy-3-oxopropoxy)-2-[(3-tert-butoxy-3-oxopropoxy)methyl]-2-(hydroxymethyl)propoxy]propanoate (1027581-61-8)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In water; for 168h; Ambient temperature;

DOI:10.1016/0040-4039(96)00008-1

Reference yield: 83.0%

4-nitro-benzoyl chloride (122-04-3) + tert-butyl 3-[3-(3-tert-butoxy-3-oxopropoxy)-2-[(3-tert-butoxy-3-oxopropoxy)methyl]-2-(hydroxymethyl)propoxy]propanoate (1027581-61-8) → 4-Nitro-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester (175724-33-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1016/0040-4039(96)00008-1

upstream raw materials:

Pentaerythritol

tert-Butyl acrylate

Downstream raw materials:

4-Nitro-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester

4-Amino-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester

4-Isothiocyanato-benzoic acid 3-(2-tert-butoxycarbonyl-ethoxy)-2,2-bis-(2-tert-butoxycarbonyl-ethoxymethyl)-propyl ester