102790-36-3

Basic information

• Product Name: 4-HYDROXYMETHYL-ISOXAZOLE
• Synonyms: ISOXAZOL-4-YL-METHANOL;4-HYDROXYMETHYL-ISOXAZOLE;AKOS PAO-1565
• CAS NO: 102790-36-3
• Molecular Formula: C4H5NO2
• Molecular Weight: 99.09
• Mol File: 102790-36-3.mol

Chemical Properties

• Boiling Point: 212.785 °C at 760 mmHg
• Flash Point: 82.49 °C
• Appearance: /
• Density: 1.25 g/cm³
• PKA: 13.59±0.10(Predicted)
• CAS DataBase Reference: 4-HYDROXYMETHYL-ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYMETHYL-ISOXAZOLE(102790-36-3)
• EPA Substance Registry System: 4-HYDROXYMETHYL-ISOXAZOLE(102790-36-3)

Safety Data

• Hazardous Substances Data: 102790-36-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDROXYMETHYL-ISOXAZOLE is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of diverse chemical entities with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-HYDROXYMETHYL-ISOXAZOLE is utilized as a key component in the production of pesticides, herbicides, and other crop protection agents. Its incorporation enhances the effectiveness of these chemicals, promoting agricultural productivity and crop health.
Used in Organic Synthesis:
4-HYDROXYMETHYL-ISOXAZOLE serves as a reagent in organic synthesis, facilitating various chemical reactions and transformations. Its presence can influence the outcome of these reactions, leading to the formation of desired products with specific properties.
Used as a Versatile Intermediate:
4-HYDROXYMETHYL-ISOXAZOLE is also employed as a versatile intermediate in the production of a wide range of organic compounds. Its ability to participate in multiple types of chemical reactions makes it an invaluable asset in the synthesis of complex organic molecules for various applications.

Upstream product

• 6455-40-9 4-(bromomethyl)-1,2-oxazole 
• 80370-40-7 ethyl isoxazole-4-carboxylate 

Downstream Products

• 65373-53-7 isoxazole-4-carbaldehyde 

Relevant articles and documents

INTEGRASE INHIBITORS 3

The present invention provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. Compounds of formula (I) are also provided.

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.

A number of novel guanine derivatives containing heterocyclic moieties at the O6-position have been synthesized using a purine quaternary salt which reacts with alkoxides under mild conditions. Initially O6-substituents were investigated in which the benzene ring of the known agent, O6-benzylguanine, was replaced by unsubstituted heterocyclic rings. The ability of these agents to inactivate the DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase), both as pure recombinant protein and in the human lymphoblastoid cell line Raji, has been compared with that of O6-benzylguanine. The present paper focuses on O6-substituents with basic rings, and under standard conditions several of them proved more effective than benzyl for inactivation of both recombinant and Raji ATase. Among the pyridine derivatives, the 2-picolyl compound 7 is not very active in contrast to the 3- and 4-picolyl compounds, and this influenced our choice of isomers of other basic ring systems for study. Since halogen substitution in the thiophene ring considerably increased the activity (17 versus 6), similar modifications in the pyridine series were examined. The more polar O6-substituents in this study are on the whole compatible with the stereochemical requirements of the ATase protein, and their pharmacological properties may be valuable in subsequent in vivo investigations, particularly the thenyl (6), 5-thiazolylmethyl (12), 5-bromothenyl (17), and 2-chloro-4-picolyl (21) derivatives.

Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition

Compounds of formula (I): STR1 (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen, aryl, cy