Inhibition of nucleoside transport by new analogues of 4- nitrobenzylthioinosine: Replacement of the ribose moiety by substituted benzyl groups
4-Nitrobenzylthioinosine (NBTI, 1) is a well-known inhibitor for the nucleoside transport protein ENT1. However, its highly polar nature is unfavorable for oral absorption and/or penetration into the CNS. In the search for compounds with lower polarity th
REAGENTS AND SYNTHETIC METHODS 52. SILANE REDUCTION OF CARBONYL COMPOUNDS IN THE PRESENCE OF IODINE.
Synthetic utility of 1,1,3,3,-tetramethyldisiloxane (TMDS) reagent under the influence of iodine is described.TMDS reagent in combination with iodine produces alkyl iodides from carbonyl compounds and oxiranes in good to excellent yields.Reduction of quinones into hydroquinones is also described.The mentioned transformations are explained from mechanistic points of view.
Lecea, B.,Aizpurua, J. M.,Palomo, C.
p. 4657 - 4666
(2007/10/02)
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