- IMIDAZOTRIAZINONE COMPOUNDS
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The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.
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Paragraph 0699; 0700
(2013/10/08)
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- BETA CARBOLINES AND USES THEREOF
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This invention provides beta-carboline compounds of formula I: wherein R1, R2, R3, R4, R5, G, and x are as described in the specification. The compounds are useful for treating cancer and inflammatory disorders.
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Page/Page column 71
(2009/06/27)
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- Substituted 5-amino-1,2,4-thiadiazoles with pharmaceutical activity
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Pharmaceutical compounds of the following formula are described: in which R1 is hydrogen, C1 4 alkyl, C1 4 alkoxy-C1 4 alkyl, hydroxy-C1 4 alkyl, optionally substituted phenyl, optionally substituted phenyl-C1 4 alkyl or a heterocycle selected from: where R3 is hydrogen, C1 4 alkyl, C1 4 alkoxy, nitro, halo, cyano, trifluoromethyl, carboxyl or -CONH2, and R4 is C1 4 alkyl; and R2 is hydrogen, C1 4 alkyl, phenyl or thienyl substituted with a carboxyl or C1 4 alkoxy-carbonyl group, an acyl group of the formula R5CO- where R5 is hydrogen, C1 4 alkyl, C1 4 alkoxy-C1 4 alkyl, halo C1 4 alkyl, C1 4 alkoxy, halo-C1 4 alkoxy, phenyl, phenyl-C1 4 alkyl, -NHC1 4 alkyl, -NH phenyl or where R6 is C1 4 alkyl, or a group of the formula -CH=C(COC1 4 alkoxy)2; or a salt thereof.
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- N-Pyrimidinylmethyl-haloacetanilide compounds and herbicidal compositions
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N-pyrimidinylmethyl-haloacetanilides of the general formula STR1 in which R1 represents hydrogen or alkyl, R2 represents hydrogen or alkyl, R3 represents hydrogen or alkyl, R4 represents hydrogen, alkyl, halogen, alkoxy or hydroxyl, R5 represents hydrogen, alkyl, halogen, alkoxy or hydroxyl, R6 represents hydrogen, alkyl, halogen, alkoxy or hydroxyl and Z represents halogen, and their use as herbicides.
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- Inhibitors of Pyrimidine Biosynthesis. Part 2. The Synthesis of Amidine Phosphonates as Potential Inhibitors of Carbamoyl Phosphate Synthase
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The synthesis of a series of amidine phosphonates (8) and (9) via a thioimidate intermediate is described.
- Wharton, Clifford J.,Wrigglesworth, Roger
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p. 433 - 436
(2007/10/02)
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