10300-69-3

Basic information

• Product Name: CHLOROACETAMIDINE HYDROCHLORIDE
• Synonyms: 2-CHLORORACETAMIDINE HYDROCHLORIDE;2-CHLOROETHANIMIDAMIDE HYDROCHLORIDE;2-CHLOROACETAMIDINE HYDROCHLORIDE;BUTTPARK 44\03-88;CHLORACETAMIDINE HYDROCHLORIDE;CHLOROACETAMIDINE HYDROCHLORIDE;2-chloroacetamidine monohydrochloride;ChloroacetamidineHCl
• CAS NO: 10300-69-3
• Molecular Formula: C₂H₅ClN₂*ClH
• Molecular Weight: 128.99
• EINECS: 233-675-7
• Product Categories: Imines/Amidines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 10300-69-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-103 °C(lit.)
• Boiling Point: 146.4 °C at 760 mmHg
• Flash Point: 42.4 °C
• Appearance: solid
• Vapor Pressure: 4.64mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Water Solubility: Insoluble in water.
• Sensitive: Moisture Sensitive
• Stability: Hygroscopic
• BRN: 3678354
• CAS DataBase Reference: CHLOROACETAMIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLOROACETAMIDINE HYDROCHLORIDE(10300-69-3)
• EPA Substance Registry System: CHLOROACETAMIDINE HYDROCHLORIDE(10300-69-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 10300-69-3(Hazardous Substances Data)

Usage

Description

Chloroacetamidine hydrochloride is an organic compound that serves as a versatile building block in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by its reactivity and ability to form stable derivatives, making it a valuable component in the development of new drugs and materials.

Uses

Used in Pharmaceutical Industry:
Chloroacetamidine hydrochloride is used as a general pharmacophore for delineating characteristics of the amidinotransferase superfamily. This application is crucial in understanding the structure, function, and potential therapeutic applications of these enzymes, which are involved in various biological processes and diseases.
Used in Chemical Synthesis:
Chloroacetamidine hydrochloride is also used as a key intermediate in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity and ability to form stable derivatives make it a valuable component in the development of new and innovative products across different industries.

InChI:InChI=1/C2H5ClN2.ClH/c3-1-2(4)5;/h1H2,(H3,4,5);1H

Upstream product

• 41264-52-2 2-chloroethanimidic acid methyl ester 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 10319-70-7 Acetamidin-2-thiolsulfat 
• 74461-64-6 3-chloromethyl-5-chloro-(1,2,4)-thiadiazole 
• 859825-10-8 7-benzyl-5,6,7,8-tetrahydro-2-(methoxymethyl)pyrido[3,4-d]pyrimidin-4(3H)-one 
• 23862-02-4 2-(chloromethyl)-6-methylpyrimidin-4-ol 
• 79651-35-7 2-chloromethyl-pyrimidin-4-ylamine 
• 919006-09-0 5-(4-bromophenyl)-2-(chloromethyl)-4-(2,4-dichlorophenyl)pyrimidine 
• 112807-11-1 3-(chloromethyl)-1,2,4-thiadiazol-5-amine 

Relevant articles and documents

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Substituted 5-amino-1,2,4-thiadiazoles with pharmaceutical activity

Pharmaceutical compounds of the following formula are described: in which R1 is hydrogen, C1 4 alkyl, C1 4 alkoxy-C1 4 alkyl, hydroxy-C1 4 alkyl, optionally substituted phenyl, optionally substituted phenyl-C1 4 alkyl or a heterocycle selected from: where R3 is hydrogen, C1 4 alkyl, C1 4 alkoxy, nitro, halo, cyano, trifluoromethyl, carboxyl or -CONH2, and R4 is C1 4 alkyl; and R2 is hydrogen, C1 4 alkyl, phenyl or thienyl substituted with a carboxyl or C1 4 alkoxy-carbonyl group, an acyl group of the formula R5CO- where R5 is hydrogen, C1 4 alkyl, C1 4 alkoxy-C1 4 alkyl, halo C1 4 alkyl, C1 4 alkoxy, halo-C1 4 alkoxy, phenyl, phenyl-C1 4 alkyl, -NHC1 4 alkyl, -NH phenyl or where R6 is C1 4 alkyl, or a group of the formula -CH=C(COC1 4 alkoxy)2; or a salt thereof.

Inhibitors of Pyrimidine Biosynthesis. Part 2. The Synthesis of Amidine Phosphonates as Potential Inhibitors of Carbamoyl Phosphate Synthase

The synthesis of a series of amidine phosphonates (8) and (9) via a thioimidate intermediate is described.