103162-77-2

Basic information

• Product Name: 4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-yl)(4-methoxyphenyl)methyl]-6-methyl-2H-chromen-2-one
• Synonyms: 4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-yl)(4-methoxyphenyl)methyl]-6-methyl-2H-chromen-2-one
• CAS NO: 103162-77-2
• Molecular Formula: C₂₈H₂₂O₇
• Molecular Weight: 470.47008
• Mol File: 103162-77-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-yl)(4-methoxyphenyl)methyl]-6-methyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-yl)(4-methoxyphenyl)methyl]-6-methyl-2H-chromen-2-one(103162-77-2)
• EPA Substance Registry System: 4-hydroxy-3-[(4-hydroxy-6-methyl-2-oxo-2H-chromen-3-yl)(4-methoxyphenyl)methyl]-6-methyl-2H-chromen-2-one(103162-77-2)

Safety Data

• Hazardous Substances Data: 103162-77-2(Hazardous Substances Data)

Upstream product

• 13252-83-0 4-hydroxy-6-methylcoumarin 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 

Relevant articles and documents

Synthesis and Antimicrobial Activity of Some New Coumarin and Dicoumarol Derivatives

Abstract: Phase transfer catalysis reaction of 4-hydroxy-6-methyl-2H-chromen-2-one with alkyl halides afforded C4 oxygen alkylation products of 2H-chromen-2-one derivatives in appreciative yield, whereas with phenyl isothiocyanate gives the C3 addition product of 4-hydroxy-6-methyl-2-oxo-N-phenyl-2H-chromene-3-carbothioamide, also one pot three component phase transfer reaction was investigated. Treatment of 4-hydroxy-6-methyl-2H-chromen-2-one with aromatic aldehydes in different molar ratios gives 3?arylidine and the dicoumarol derivatives. However pyrano chromene and pyrano pyridine were obtained by reaction of arylidine with ethyl acetoacetate through Michael cycloaddition reaction. The stability of pyrone ring in 3-arylidine and dicoumarol towards different nucleophilic reagents under reflux and/or fusion conditions has been studied by the action of, hydrazine hydrate, ammonium acetate, methyl amine and p-toluidine afforded compounds 1,2-bis(benzo[d][1,3]dioxol-5-ylmethylene)hydrazine, 1,2-bis(4-methoxybenzylidene)hydrazine and 2,6-bis((2,6-dihydroxy-3-methylphenyl)(hydroxy)methylene)-1-(4-methoxyphenyl)-4-(p-tolyl) piperidine-3,5-dione derivatives. The antimicrobial activity of some synthesized compounds has been investigated.

Synthesis and antimicrobial activity of some new coumarin and dicoumarol derivatives

PTC reaction of coumarin derivative 1 with alkyl halides afforded C4 oxygen alkylation products 2a-d in appreciative yield, whereas with phenyl isothiocyanate gives the C3 addition product 4; also, one-pot three-component PTC reactio

Anti-leishmanial activities of synthetic biscoumarins

Synthetic biscoumarins 1-19 were screened to check their anti-leishmanial activity. Out of nineteen, analogs 2 (IC50 = 46.95 ± 1.23 μM), 4 (IC50 = 63.03 ± 0.20 μM), 5 (IC50 = 41.35 ± 0.51 μM), 6 (IC50 = 35.62 ±

Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton

In our effort directed toward the discovery of new anti-diabetic agent for the treatment of diabetes, a library of biscoumarin derivative 1-18 was synthesized and evaluated for α-glucosidase inhibitory potential. All eighteen (18) compounds displayed asso

COUMARIN-BASED COMPOUNDS

Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compoun

Synthesis of monomethylated dimeric benzopyrans as HIV-1 and HIV-2 inhibitors: Part I

Mono methylated dimeric coumarins have been synthesized by condensation of 6- or 8-methyl-4-hydroxycoumarins with different aromatic aldehydes. Twenty three compounds of the two series have been screened for anti-HIV activity against HIV-1 and HIV-2 strai