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p-Anisaldehyde
Cas No: 123-11-5
No Data 1 Gram 1-1000 Metric Ton/Day Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
p-Anisaldehyde
Cas No: 123-11-5
No Data 1 Kilogram Unlimited Kilogram/Day Jiangxi LinQ Spices Co.,Ltd. Contact Supplier
Nature Anisic aldehyde
Cas No: 123-11-5
No Data 1 Kilogram 1 Metric Ton/Day Huangshan Honghui Pharm Technology Co., Ltd. Contact Supplier
Top purity 4-Methoxybenzaldehyde with high quality cas:123-11-5
Cas No: 123-11-5
USD $ 15.0-50.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality 4-Methoxybenzaldehyde supplier in China
Cas No: 123-11-5
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
4-Methoxybenzaldehyde
Cas No: 123-11-5
USD $ 12.0-12.0 / Kilogram 1 Kilogram 500 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
p-Anisaldehyde
Cas No: 123-11-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
High Quality Food Grade p-Anisaldehyde 123-11-5 HACCP Manufacturer
Cas No: 123-11-5
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
p-Anisaldehyde
Cas No: 123-11-5
USD $ 2.0-3.0 / Kilogram 1 Kilogram 100 Metric Ton/Week EAST CHEMSOURCES LIMITED Contact Supplier
High Quality 4-Methoxybenzaldehyde
Cas No: 123-11-5
No Data 1 1 Ality Chemical Corporation Contact Supplier

123-11-5 Usage

Description

p-Methoxybenzaldehyde has a characteristic hawthorne odor and a pungent, anise-like flavor. It has a bitter flavor above 30 - 40 ppm. May be prepared by methylation and oxidation of p-cresol and also by oxidation of anethole.

Chemical Properties

Colorless or light yellow liquid ; Cured getting cold. The relative density : 1.119-1.123, the refractive index: 1.5710-1.5750; boiling point: 246-248℃; melting point: 1-2.5℃; flash point 100℃above. Dissolved in 2 volumes of 60% ethanol. Mutually dissolvable with oil flavor. Acid value < 6.0 .The scent of the flower is like the Hawthorn flower, while the scent of the beans is like the scent of vanilla bean. It has some sweetness of herbs and spices. The fragrance is strong, and lasts for quite long time.

FEMA limits

FEMA (mg/kg): Soft drinks 6.3; cold drink 5.6; candy 14; baked goods 16; puddings class from 0.5 to 30; gum from 18 to 76.Moderate limit(FDA§172.515,2000).The concentration of the final product is generally 5~30mg/kg.

Chemical Properties

p-Methoxybenzaldehyde has a sweet, floral odor and a pungent, anise-like flavor. It has a bitter flavor above 30 to 40 ppm.

Product description

Anisaldehyde(Anisic aldehyde),also known as anisaldehyde,4-methoxybenzaldehyde, anisaldehyde, anise aldehyde, is colorless to pale yellow liquid at room temperature with a similar smell of hawthorn. Density 1.123g/cm3 (20 ℃). Melting point 2℃. The boiling point is 249.5. The refractive index is 1.5731. It is difficult to dissolve in water (solubility in water 0.3%), slightly soluble in propylene glycol, glycerin, soluble in ethanol, ether, acetone, chloroform and other most organic solvents. It can be volatiled with the steam. It exists in the oil of anise, fennel oil, dill oil, Acacia flowers, vanilla extract in nature, obtained by oxidation and separation. The synthesized methods are as follows:(1) Phenol is methylated with dimethyl sulfate, and then it is followed by the reaction of chlorine methylation, hydrolysis; (2) p-cresol is methylated and then obtained by further oxidized; (3) It can be obtained through methylation of p-hydroxybenzaldehyde. It is mainly used as flavor base of hawthorn, sunflower, lilac and other flavors, blending spices of new treasure, white gold Albizia julibrissin, Acacia, grass perfume and other flavors, co-flavoring agents of Lily fragrance and modified agent of sweet scented osmanthus flavor. Tetra (p-methoxyphenyl) porphyrin and cobalt complexes can be synthetized by methoxy benzaldehyde and pyrrole as raw materials, in the reaction system of propionic acid as solvent and chloroacetic acid as catalyst. As an excellent bright agent for non-cyanide zinc plating DE additive, it can improve the anodic polarization over a wide current range, get bright coating, to create favorable conditions for environmental protection. Anti-microbial drugs cefadroxil benzyl penicillin derived from anisaldehyde in the pharmaceutical industry for the manufacture is an intermediate of antihistamine drugs. It is allowed for the use of edible spices conformed to China's GB2760-86 regulations .It is mainly for the preparation of essence of vanilla, spices, apricot, cream, fennel, caramel, cherry, chocolate, walnuts, raspberry, strawberry, mint and so on. Methoxycinnamic aldehyde can be obtained through condensation of anisaldehyde and acetaldehyde in alkaline conditions.

Production method

It can be obtained through p-cresol methyl ether from the p-cresol by methylation and then oxidation by adding manganese dioxide and sulfuric acid. Or it is derived from the oxidation of anisole. Anise aldehyde is mainly included in anise oil, fennel oil, dill oil, gold Albizia julibrissin oil, vanilla extract, etc. When extracted from natural raw materials, it is oxidated by ozone, nitric acid, potassium permanganate, sodium dichromate or sulfuric acid, in the presence of p-Aminobenzene Sulfonic. It can also be obtained as follows: Anethole is Isolated from the essential oil, then decomposed by yellow blood salt, water, sodium bisulfite and other appropriate decomposing agent, cutting off the allyl double bond and generating anise aldehyde. According to the method, the yield was 60%. It had been discovered and synthesized before it has been isolated from the essential oil. The product can be prepared to take from phenol and anisole, cresol ether, preparation of p-hydroxybenzaldehyde and other raw materials. Using dimethyl sulfate for methylation of phenol, followed by chloromethylation reaction Fennel introducing chloromethyl ether and Urotropine with salt, and then hydrolyzed to chloromethyl into aldehyde (Suo Mulai reaction) to prepare p-methoxy benzaldehyde. Another promising approach is to turn on the methylation of toluene, the formation of methyl phenyl ether, and then oxidation to obtain the production. In foreign countries, the current method is using oxidating p-methyl anisole in sulfuric acid in the presence of the oxidizing agent such as potassium dichromate, potassium permanganate and manganese dioxide.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 42, p. 1041, 1994 DOI: 10.1248/cpb.42.1041Tetrahedron Letters, 43, p. 1395, 2002 DOI: 10.1016/S0040-4039(02)00027-8

Taste threshold values

Taste characteristics at 5 to 10 ppm: sweet powdery, vanilla creamy, spice anise, nutty, cherry pit and almond-like nuances.

Metabolism

Anisic aldehyde undergoes a very slight degree of demethylation with oxidation of its aldehyde group to an acid group, the major metabolite excreted being anisic acid (Williams, 1959).

Content Analysis

0.8g of anisaldehyde is accurately weighed, and determined according to the method of aldehyde and ketone determination (OT-7) or the method of determination of two or aldehyde (OT-6).The time of the reactional placement for samples and control samples are 1.5 minutes respectively. Calculation of the equivalent factor (E) is to take 68.08. Or it can be measured by gas chromatography (GT-10-4) nonpolar column method.

Safety Profile

Moderately toxic by ingestion. A skin irritant. Mutation data reported. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes

Aroma threshold values

Aroma characteristics at 1.0%: sweet powdery, spicy creamy, fruity, vanilla and hay-like. Coumarin, almond, anisic with berry nuances.

Chemical Properties

p-Anisaldehyde occurs in many essential oils, often together with anethole. It is a colorless to slightly yellowish liquid with a sweet, mimosa, hawthorn odor. p-Anisaldehyde can be hydrogenated to anise alcohol and readily oxidizes to anisic acid when exposed to air. Synthetic routes to anisaldehyde start from p-cresyl methyl ether, which is oxidized, for example, by manganese dioxide or by oxygen or peroxy compounds in the presence of transition metal catalysts .Another industrial process uses electrochemical oxidation in the presence of lower aliphatic alcohols via the corresponding anisaldehyde dialkyl acetal . Anisaldehyde may also be produced by methylation of 4-hydroxybenzaldehyde, which is easily obtained by oxidation of p-cresol or by Vilsmeier formylation of anisol.

Occurrence

Reported found in essential oils and extracts of vanilla, Acacia farmesiana Willd., Magnoila salicifolia Maxim., Erica arborea, Pirus communis, Boswellia serrata, and others; also in anise, fennel and star anise (especially when aged due to the oxidation of anethole), cranberry, black currant, cinnamon and basil.

Preparation

By methylation and oxidation of p-cresol and also by oxidation of anethole.

Toxicity

ADI 1mg/kg(CE). LD50 1510 mg/kg(Rat, Oral). No evident abnormal showed in the process of growth, blood, tissues from rats which were either raised by feeds containing 1000 mg/kg anise aldehyde for 27~28 weeks or raised by feeds containing 10000 mg/kg anise aldehyde for 15 weeks.

Uses

p-Anisaldehyde is a flavoring agent that is a colorless or faintly yellow liquid, hawthorn-like odor. It is miscible in alcohol, ether, and most fixed oils, soluble in propylene glycol, insoluble in glycerin, water, and mineral oil. It is obtained by synthesis. It is also termed anise aldehyde and p-methoxybenzaldehyde.

Uses

p-Anisaldehyde is the main body of floral perfumes for the deployment of Hawthorn. It can also be used for lilac, orchid, sunflower, acacia, shy flower, black locust, magnolia, wallflowers and sweet bean curd and other floral and new treasure, Hong Wei, aldehyde and other non-fragrant flower essences. It can also be used for other heavy woody sandalwood flavor as well as used in soap flavor. Its sweetness is used in the food and to reconcile flavor. p-Anisaldehyde has a persistent aroma of hawthorn. It is used as the main spice in hawthorn flowers, sunflower, lilac flavor; Lily of the valley as a flavoring agent in flavor; it can also be used as modifier in the sweet-scented osmanthus flavor as well as for daily flavors and food flavor. The product is allowed for the temporary use of edible spices under China GB2760-86 provisions. It is mainly used for mint flavor of preparation of vanilla, incense and spice, apricot, cream, fennel, caramel, cherry, chocolate, walnuts, raspberry, strawberry, etc. The effect is very good when cooperating with the orange essential oil. As an excellent bright agent for non-cyanide zinc plating DE additive, it can improve the anodic polarization over a wide current range, get bright coating, to create favorable conditions for environmental protection. Anti-microbial drugs cefadroxil benzyl penicillin derived from anisaldehyde in the pharmaceutical industry for the manufacture is an intermediate of antihistamine drugs. It can be used for the preparation and organic synthesis of perfume.

Uses

Perfumery and toilet soaps; odor resembles that of coumarin, but the aldehyde must be mixed with other odorous substances to yield an agreeable odor. Also used in organic syntheses.

Purification Methods

Wash the aldehyde with saturated aqueous NaHCO3, then H2O, steam distil, extract the distillate with Et2O, dry (MgSO4) the extract, filter and distil this under a vacuum and N2. Store it in glass ampules under N2 in the dark. [Beilstein 8 IV 252.]

Chemical Properties

clear colorless to pale yellowish liquid

odor

There is a strong anise-like aroma and hawthorn. It is fresh, green fennel aroma. The scent of the flower is like the Hawthorn flower, while the scent of the beans is like the scent of vanilla bean. It has some sweetness of herbs and spices. The fragrance is strong, and lasts for quite long time. There is stronger and clearer alcohol and rougher than anise. The above information is edited by the Chemicalbook of Tian Ye.
InChI:InChI=1/C8H8O2/c1-10-8-4-2-7(6-9)3-5-8/h2-6H,1H3

123-11-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (A0480)  p-Anisaldehyde  >99.0%(GC) 123-11-5 25mL 100.00CNY Detail
TCI America (A0480)  p-Anisaldehyde  >99.0%(GC) 123-11-5 500mL 525.00CNY Detail
Alfa Aesar (A15364)  4-Methoxybenzaldehyde, 98%    123-11-5 50g 194.0CNY Detail
Alfa Aesar (A15364)  4-Methoxybenzaldehyde, 98%    123-11-5 250g 394.0CNY Detail
Alfa Aesar (A15364)  4-Methoxybenzaldehyde, 98%    123-11-5 1000g 951.0CNY Detail
Sigma-Aldrich (97063)  p-Anisaldehyde  analytical standard 123-11-5 97063-1ML-F 327.60CNY Detail
Sigma-Aldrich (97063)  p-Anisaldehyde  analytical standard 123-11-5 97063-5ML-F 1,035.45CNY Detail
USP (1036937)  p-Anisaldehyde  United States Pharmacopeia (USP) Reference Standard 123-11-5 1036937-3X500MG 4,647.24CNY Detail
Sigma-Aldrich (05320590)  p-Anisaldehyde  primary pharmaceutical reference standard 123-11-5 05320590-50MG 5,400.72CNY Detail

123-11-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Anisic aldehyde

1.2 Other means of identification

Product number -
Other names Obepin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-11-5 SDS

123-11-5Synthetic route

4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With 2,2'-bipyridylchromium peroxide In benzene for 0.8h; Heating;100%
With tris(4-methylphenyl)bismuthine oxide In toluene for 2h; Ambient temperature;100%
With 2,2'-bipyridylchromium peroxide In benzene for 0.8h; Product distribution; Heating; effect of various chromium(VI) based oxidants;100%
2-(4-methoxyphenyl)-1,3-dithiane
24588-72-5

2-(4-methoxyphenyl)-1,3-dithiane

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With tetrafluoroboric acid; mercury(II) oxide In tetrahydrofuran Ambient temperature;100%
With silica gel; ferric nitrate In hexane at 50℃; for 0.166667h;100%
With silica gel; copper(II) nitrate In tetrachloromethane for 0.416667h; Ambient temperature;98%
4-methoxybenzaldehyde diethylacetal
2403-58-9

4-methoxybenzaldehyde diethylacetal

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water at 80℃; for 2h;100%
With trifluoroacetic acid In dichloromethane at 25℃; for 20h;86%
With hydrogenchloride; sodium docusate In n-heptane at 25℃; Rate constant; variation of H3O(1+) concentration;
1-(4-methoxyphenyl)-2-phenylethan-1-ol
5422-47-9

1-(4-methoxyphenyl)-2-phenylethan-1-ol

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; sodium acetate In water; acetonitrile Mechanism; Ambient temperature; other 2-aryl-1-(4-methoxyphenyl)ethanols;100%
p-Anisaldehyde dimethyl acetal
2186-92-7

p-Anisaldehyde dimethyl acetal

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With polymer-supported dicyanoketene acetal; water In acetonitrile at 20℃; for 0.5h; Hydrolysis;100%
sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In water at 30℃; for 0.0833333h;100%
With iodine In dichloromethane at 0℃;100%
(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(4-methoxybenzyloxymethyl)-ethyl>-5-methyltetrahydropyran-2-yl>butane
96181-80-5

(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(4-methoxybenzyloxymethyl)-ethyl>-5-methyltetrahydropyran-2-yl>butane

A

(S)-2-<(2R,3S,6R)-6-<(S)-1-(benzyloxymethyl)propyl>-3-methyltetrahydropyran-2-yl>propan-1-ol
107207-23-8

(S)-2-<(2R,3S,6R)-6-<(S)-1-(benzyloxymethyl)propyl>-3-methyltetrahydropyran-2-yl>propan-1-ol

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In dichloromethane; water for 1h; Ambient temperature;A 100%
B n/a
Sodium; 6-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-hexanoate

Sodium; 6-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-hexanoate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With hydrogenchloride for 0.0416667h; Product distribution; Ambient temperature; pH = 4-6, regeneration of aldehyde;100%
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; for 0.05h; Microwave irradiation;100%
hydrotalcite In dimethyl sulfoxide at 140℃; for 1.5h; Kornblum reaction;96%
With 1-dodecyl-3-methylimidazolium iron chloride; periodic acid at 30℃; for 1.5h;95%
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; for 0.05h; Microwave irradiation;100%
With dihydrogen peroxide In ethanol for 4h; Reflux; Green chemistry;96%
With pyridine N-oxide for 0.0111111h; Irradiation; with microwave irradiation;92%
4-methoxybenzaldehyde-1,1-diacetate
14202-31-4

4-methoxybenzaldehyde-1,1-diacetate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With [NO(1+)*18-crown-6*H(NO3)2(1-)]; silica gel In dichloromethane at 20℃; for 0.0833333h;100%
With sulphated zirconia In acetonitrile at 60℃; for 0.3h; Microwave irradiation;100%
With iron(II) sulfate In dichloromethane for 0.166667h; Heating;99%
4-Methoxystyrene
637-69-4

4-Methoxystyrene

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With sodium periodate; C31H29Br2N3Ru*CH2Cl2 In water; ethyl acetate; acetonitrile at 25℃; for 0.5h; Inert atmosphere; Schlenk technique;100%
With ruthenium trichloride; [bis(acetoxy)iodo]benzene In dichloromethane; water at 30℃; for 2.5h; Solvent;92.1%
With dihydrogen peroxide In acetonitrile at 65℃; for 6h;92%
(E)-2-(4-methoxybenzylidene)hydrazine carboxamide
120445-53-6

(E)-2-(4-methoxybenzylidene)hydrazine carboxamide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With caro's acid; silica gel In dichloromethane for 0.583333h; Heating;100%
bismuth(III) chloride In tetrahydrofuran; water for 0.0833333h; catalysed cleavage; microwave irradiation;72%
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With sodium carbonate; dimethyl sulfate In water99.9%
With potassium carbonate In acetone
With halomethane In acetone
4-Methylanisole
104-93-8

4-Methylanisole

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With oxygen In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 24h; Irradiation;99%
With cerium (IV) ammonium nitrate In methanol; benzene96.3%
With carbon tetrabromide; oxygen In acetonitrile at 20℃; for 2h; Irradiation; Green chemistry;96%
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With tri-n-butyl-tin hydride; triphenylphosphine; indium(III) chloride In tetrahydrofuran at 0℃; for 2h; Reduction;99%
With pentacoordinated hydrogenosilane 191%
With hydrogenchloride; samarium; tributylphosphine In acetonitrile at -20℃; for 1h;90%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
Stage #1: p-methoxyl benzaldoxime With hexachlorodisilane; silica gel In toluene at 110℃; for 0.5h;
Stage #2: With water In toluene for 0.5h;
99%
With silica chromate; silica gel for 0.0333333h; microwave irradiation;98%
With 3-carboxypyridinium chlorochromate In dichloromethane for 0.75h; Heating;97%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With silica gel; periodic acid at 20℃; for 0.25h; Neat (no solvent);99%
With dimanganese decacarbonyl In toluene at 120℃; Sealed tube;93%
With aluminum oxide; potassium metaperiodate for 0.166667h; Microwave irradiation;92%
4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccasefrom Trametes versicolor; oxygen In water at 30℃; for 24h; pH=4.5; Time; Enzymatic reaction;99%
With 2,6-dimethylpyridine; nitroxyl radical; sodium perchlorate In water; acetonitrile for 5h; Oxidation; Electrochemical reaction;98.2%
With cercosporin; oxygen In methanol at 20℃; Schlenk technique; Irradiation; Green chemistry; chemoselective reaction;97%
2-(4-methoxyphenyl)-1,3-dioxolane
2403-50-1

2-(4-methoxyphenyl)-1,3-dioxolane

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water at 80℃; for 0.25h; microwave irradiation;99%
With n-butyltriphenylphosphonium peroxodisulfate In acetonitrile for 1.5h; Heating;98%
With iron(III) chloride hexahydrate; acetaldehyde In dichloromethane at 20℃; for 0.25h;98%
α-(2-cyanoethyl)-4,4'-dimethoxybenzoin
174869-04-6

α-(2-cyanoethyl)-4,4'-dimethoxybenzoin

A

4-(4-methoxy-phenyl)-4-oxo-butyronitrile
55234-56-5

4-(4-methoxy-phenyl)-4-oxo-butyronitrile

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With potassium cyanide In N,N-dimethyl-formamide at 80℃; for 1h;A 99%
B n/a
1-(4-Methoxy-phenyl)-1-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-2-phenyl-ethanol

1-(4-Methoxy-phenyl)-1-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-2-phenyl-ethanol

A

4-benzyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
53645-66-2

4-benzyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With potassium cyanide In N,N-dimethyl-formamide for 1h; Heating;A 99%
B n/a
4-Methoxybenzyl alcohol
105-13-5

4-Methoxybenzyl alcohol

A

p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With dihydrogen peroxide; methyltrioxorhenium(VII); sodium bromide In acetic acid for 10h; Ambient temperature;A 99%
B 1%
4-methoxy-N,N-diethylbenzamide
7465-86-3

4-methoxy-N,N-diethylbenzamide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.25h;99%
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.5h; Product distribution / selectivity;99%
With Schwartz's reagent In tetrahydrofuran at 20℃; for 0.5h; Solvent; Inert atmosphere;99%
p-methoxybenzyl acetate
104-21-2

p-methoxybenzyl acetate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With methanol; potassium permanganate In ethyl acetate at 25℃; for 24h;99%
Stage #1: p-methoxybenzyl acetate With NADPH; acetylesterase; Aryl alcohol oxidase; aryl alcohol dehydrogenase; water; oxygen at 37℃; for 0.0833333h; Enzymatic reaction; Borate buffer;
Stage #2: With 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one; horse radish peroxidase at 37℃; for 0.0666667h; Enzymatic reaction; Citric buffer;
Multi-step reaction with 2 steps
1: lipase B from Candida antarctica immobilized on Immobead 150 / aq. phosphate buffer / 0.33 h / 40 °C / pH 7.4
2: 9-azabicyclo<3.3.1>nonane-N-oxyl; copper(I) bromide; 1-methyl-1H-imidazole / water / 2 h / 20 °C
View Scheme
benzyl-(4-methoxybenzyl)amine
14429-02-8

benzyl-(4-methoxybenzyl)amine

A

benzaldehyde
100-52-7

benzaldehyde

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccasefrom Trametes versicolor; oxygen In water at 30℃; for 24h; pH=4.5; Enzymatic reaction;A n/a
B 99%
methoxybenzene
100-66-3

methoxybenzene

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With pyridine; bis(trichloromethyl) carbonate In chloroform at 0 - 5℃; for 6h;
Stage #2: With aluminum (III) chloride at 20 - 30℃; for 0.7h;
Stage #3: methoxybenzene at 80 - 85℃; for 12h; Time; Temperature;
98.2%
With methanesulfonyl chloride at 20 - 100℃; for 1h;91.1%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate In acetonitrile at -5℃; for 1h;
Stage #2: methoxybenzene With copper(II) nitrate In acetonitrile at 20℃; for 12h; Vilsmeier-Haack Formylation;
Stage #3: With water In acetonitrile Kinetics; Mechanism; Catalytic behavior; Reagent/catalyst; Time; Solvent; Temperature; Vilsmeier-Haack Formylation; Heating;
67%
trimethyl(4-methoxybenzyloxy)silane
14629-56-2

trimethyl(4-methoxybenzyloxy)silane

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With n-butyltriphenylphosphonium peroxodisulfate In acetonitrile for 0.166667h; Heating;98%
With N-benzyl-N,N-dimethyl anilinium peroxodisulfate In acetonitrile for 0.1h; Reflux;96%
With Montmorillonite K10; ferric nitrate Oxidation; deprotection; Irradiation;95%
2-(4-methoxyphenyl)-[1,3]dithiolane
6712-20-5

2-(4-methoxyphenyl)-[1,3]dithiolane

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With silica gel; copper(II) nitrate In tetrachloromethane for 0.25h; Ambient temperature;98%
With silica gel In neat (no solvent) at 20℃; for 0.0333333h;98%
With ferric nitrate Ambient temperature;97%
((4-methoxyphenyl)methylene)bis(phenylsulfane)
23837-10-7

((4-methoxyphenyl)methylene)bis(phenylsulfane)

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With bismuth(III) nitrate In benzene for 12h; Ambient temperature;98%
With thionyl chloride; dihydrogen peroxide In acetonitrile at 25℃; for 0.0166667h;95%
With β‐cyclodextrin; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In acetone at 20℃; for 0.5h;89%
With sodium perborate In acetic acid at 25℃; for 1h;85%
With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile for 1h; Ambient temperature;78%
4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

3,3-(4'-methoxybenzylidene)bis(4-hydroxycoumarin)
10172-75-5

3,3-(4'-methoxybenzylidene)bis(4-hydroxycoumarin)

Conditions
ConditionsYield
With 4-sulfophthalic acid In water at 80℃; for 0.416667h; Catalytic behavior; Green chemistry;100%
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 16h;99%
With phosphotungstic acid In water at 80℃; for 0.383333h; domino Knoevenagel type condensation/Michael reaction;99%
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one
3327-24-0

1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water Claisen-Schmidt Condensation;100%
Stage #1: o-hydroxyacetophenone With sodium hydroxide In ethanol; water at 0 - 5℃;
Stage #2: 4-methoxy-benzaldehyde In ethanol; water
100%
With sodium hydroxide In ethanol at 20℃;95%
Nitroethane
79-24-3

Nitroethane

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4-(2-nitro-propenyl)-anisole
17354-63-1

4-(2-nitro-propenyl)-anisole

Conditions
ConditionsYield
With ammonium acetate at 110℃; for 72h;100%
With ammonium acetate Henry reaction; Reflux;94%
With ammonium acetate at 120℃; for 2h;93%
4-Iodoacetophenone
13329-40-3

4-Iodoacetophenone

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

(E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
92855-02-2

(E)-1-(4-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4.25h; Cooling with ice;100%
With sodium hydroxide In methanol at 0 - 20℃; for 4h; Claisen-Schmidt condensation;91%
With SiO2-H3PO4 Aldol Condensation; Microwave irradiation;88%
4,4'-thiobisaniline
139-65-1

4,4'-thiobisaniline

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

bis-[4-(4-methoxy-benzylidenamino)-phenyl]-sulfide
3430-65-7

bis-[4-(4-methoxy-benzylidenamino)-phenyl]-sulfide

Conditions
ConditionsYield
With piperidine In ethanol100%
With ethanol; zinc(II) chloride
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

dimedone
126-81-8

dimedone

9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-dione
19419-25-1

9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-2,3,4,5,6,7,8,9-octahydro-1H-xanthene-1,8-dione

Conditions
ConditionsYield
With poly[(2-acrylamido-2-methylpropane sulfonic acid)-co-(acrylic acid)-co-(vinyl functionalized halloysite clay)] In water at 20℃; for 3h;100%
With N-sulfonic acid poly(4-vinylpyridinium) chloride at 100℃; for 0.166667h;98%
With phospho sulphonic acid In neat (no solvent) at 110℃; for 0.5h; Green chemistry;98%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

4-methoxy-aniline
104-94-9

4-methoxy-aniline

N-(4-methoxy benzylidene)-4-methoxyaniline
1749-08-2

N-(4-methoxy benzylidene)-4-methoxyaniline

Conditions
ConditionsYield
In ethanol for 1h; Sonication;100%
With magnesium sulfate In dichloromethane at 20℃; for 72h;99%
In ethyl 2-hydroxypropionate; water at 20℃; for 0.05h;93%

123-11-5Related news

Molecular structure of p-Anisaldehyde (cas 123-11-5) from electron diffraction☆09/25/2019

The molecular structure of p-anisaldehyde has been determined by electron diffraction. The experimental data are consistent with a planar model with a fairly low barrier torsional motion about the phenyl-methoxy linkage. This barrier is estimated to be between 3.5 and 12 kJ mol−1. Appreciable an...detailed

Biosynthesis of p-Anisaldehyde (cas 123-11-5) by the white-rot basidiomycete Pleurotus ostreatus09/10/2019

The white-rot basidiomycete Pleurotus ostreatus produced sweet flavor compounds on a liquid medium. The major and minor compounds identified by GC-MS analysis were p-anisaldehyde (4-methoxybenzaldehyde) and 3-chloro-p-anisaldehyde (3-chloro-4-methoxybenzaldehyde), respectively. p-Anisaldehyde wa...detailed

Efficacy of a combination of nisin and p-Anisaldehyde (cas 123-11-5) against Listeria monocytogenes09/08/2019

Nisin is used as a food-safe antimicrobial agent and has been widely applied to daily food products to prevent bacterial growth. However, the practical application of nisin is limited. Although nisin inhibits the growth of Listeria monocytogenes, exposure to this agent is also a risk factor for ...detailed

Synergistic antimicrobial effects of nisin and p-Anisaldehyde (cas 123-11-5) on Staphylococcus aureus in pasteurized milk09/07/2019

Staphylococcus aureus (S. aureus) infections resistant to a variety of drugs have been increasingly documented in recent years. Drug resistance has appeared largely due to extensive use of antibiotics. Nisin has been widely used in food industry to prevent bacterial growth. However, nisin resist...detailed

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