Pd-catalysed carbonylative annulation of salicylaldehydes with benzyl chlorides using N-formylsaccharin as a CO surrogate
A convenient and highly efficient Pd-catalysed carbonylative annulation of salicylaldehydes with benzyl chlorides to afford the corresponding 3-arylcoumarins in good to excellent yields has been developed. Importantly, the protocol utilizes a commercially available, low cost, solid and easy to handle N-formylsaccharin as an alternative to the highly toxic CO gas.
Yadav, Vinod K.,Srivastava, Vishnu P.,Yadav, Lal Dhar S.
supporting information
p. 16281 - 16286
(2018/10/04)
A complete switch of the directional selectivity in the annulation of 2-hydroxybenzaldehydes with alkynes
Controlling reaction selectivity is an eternal pursuit for chemists working in chemical synthesis. As part of this endeavor, our group has been exploring the possibility of constructing different natural product skeletons from the same simple starting mat
Zeng, Huiying,Li, Chao-Jun
supporting information
p. 13862 - 13865
(2015/01/09)
Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes
The condensation reaction of 2-chloro-2-arylacetaldehyde with salicylaldehyde catalyzed by N-heterocyclic carbene (NHC) leading to 3-arylcoumarin was studied. A number of 3-arylcoumarin derivatives were obtained in good to excellent yields via this umpolung reaction. This reaction is facile and experimentally simple and mild.
Jiang, Yuansong,Chen, Wanzhi,Lu, Weimin
p. 3669 - 3676
(2013/05/08)
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