1031927-05-5

Basic information

• Product Name: 6,8-di-tert-butyl-3-phenylcoumarin
• Synonyms: 6,8-di-tert-butyl-3-phenylcoumarin
• CAS NO: 1031927-05-5
• Molecular Weight: 334.458
• Mol File: 1031927-05-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6,8-di-tert-butyl-3-phenylcoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-di-tert-butyl-3-phenylcoumarin(1031927-05-5)
• EPA Substance Registry System: 6,8-di-tert-butyl-3-phenylcoumarin(1031927-05-5)

Safety Data

• Hazardous Substances Data: 1031927-05-5(Hazardous Substances Data)

Upstream product

• 37942-07-7 3,5-di-tert-butyl-2-hydroxybenzaldehyde 
• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 100-44-7 benzyl chloride 
• 536-74-3 phenylacetylene 
• 122-78-1 phenylacetaldehyde 
• 1004-99-5 2-chloro-2-phenylethanol 
• 96-09-3 styrene oxide 
• 100-52-7 benzaldehyde 
• 4638-79-3 2-chloro-2-phenylacetaldehyde 

Relevant articles and documents

Pd-catalysed carbonylative annulation of salicylaldehydes with benzyl chlorides using N-formylsaccharin as a CO surrogate

A convenient and highly efficient Pd-catalysed carbonylative annulation of salicylaldehydes with benzyl chlorides to afford the corresponding 3-arylcoumarins in good to excellent yields has been developed. Importantly, the protocol utilizes a commercially available, low cost, solid and easy to handle N-formylsaccharin as an alternative to the highly toxic CO gas.

Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes

The condensation reaction of 2-chloro-2-arylacetaldehyde with salicylaldehyde catalyzed by N-heterocyclic carbene (NHC) leading to 3-arylcoumarin was studied. A number of 3-arylcoumarin derivatives were obtained in good to excellent yields via this umpolung reaction. This reaction is facile and experimentally simple and mild.