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3-Bromo-4-(tert-butyl)aniline, with the molecular formula C10H14BrN, is a substituted aniline derivative characterized by the presence of a bromine atom at the 3rd carbon and a tert-butyl group at the 4th carbon of the aniline ring. This chemical compound is recognized for its structural features and reactivity, making it a versatile building block in various chemical and pharmaceutical applications.

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  • 103275-21-4 Structure
  • Basic information

    1. Product Name: 3-BroMo-4-(tert-butyl)aniline
    2. Synonyms: 3-BroMo-4-(tert-butyl)aniline
    3. CAS NO:103275-21-4
    4. Molecular Formula: C10H14BrN
    5. Molecular Weight: 228.12886
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 103275-21-4.mol
  • Chemical Properties

    1. Melting Point: 29-29.5 °C
    2. Boiling Point: 125 °C(Press: 1 Torr)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.306±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    8. Solubility: N/A
    9. PKA: 3.85±0.10(Predicted)
    10. CAS DataBase Reference: 3-BroMo-4-(tert-butyl)aniline(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-BroMo-4-(tert-butyl)aniline(103275-21-4)
    12. EPA Substance Registry System: 3-BroMo-4-(tert-butyl)aniline(103275-21-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 103275-21-4(Hazardous Substances Data)

103275-21-4 Usage

Uses

Used in Organic Synthesis:
3-Bromo-4-(tert-butyl)aniline is utilized as a key building block in organic synthesis for the production of a wide range of organic compounds. Its unique structure and reactivity facilitate the synthesis of complex organic molecules, contributing to the development of new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Bromo-4-(tert-butyl)aniline serves as an essential component in the research and development of new drugs. Its structural features and reactivity make it a valuable tool for the synthesis of bioactive molecules with potential therapeutic applications.
Used in Dye and Pigment Production:
3-Bromo-4-(tert-butyl)aniline is employed in the production of dyes and pigments, where its chemical properties contribute to the creation of colorants with specific characteristics. Its use in this industry helps in developing colorants with improved properties, such as stability and color intensity.
Used in Material Science:
3-Bromo-4-(tert-butyl)aniline may have potential applications in the field of material science, where its structural features and reactivity can be leveraged to develop new materials with specific properties. These materials could have applications in various industries, including electronics, coatings, and plastics.
Used in Medicinal Chemistry:
Due to its structural features, 3-Bromo-4-(tert-butyl)aniline may have potential applications in medicinal chemistry. It could be used as a starting material or intermediate in the synthesis of pharmaceutical compounds, contributing to the development of new drugs with improved efficacy and safety profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 103275-21-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,7 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 103275-21:
(8*1)+(7*0)+(6*3)+(5*2)+(4*7)+(3*5)+(2*2)+(1*1)=84
84 % 10 = 4
So 103275-21-4 is a valid CAS Registry Number.

103275-21-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Bromo-4-(tert-butyl)aniline

1.2 Other means of identification

Product number -
Other names 3-bromo-4-tert-butylaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103275-21-4 SDS

103275-21-4Relevant articles and documents

Nucleophilic Iron Complexes in Proton-Transfer Catalysis: An Iron-Catalyzed Dimroth Cyclocondensation

Baykal, Aslihan,Zhang, Dihan,Knelles, Jakob,Alt, Isabel T.,Plietker, Bernd

, p. 3003 - 3010 (2019)

The nucleophilic iron complex Bu4N[Fe(CO)3(NO)] (TBA[Fe]) is an active catalyst in C?H-amination but also in proton-transfer catalysis. Herein, we describe the successful use of this complex as a proton-transfer catalyst in the cyclocondensation reaction between azides and ketones to the corresponding 1,2,3-triazoles. Cross-experiments indicate that the proton-transfer catalysis is significantly faster than the nitrene-transfer catalysis, which would lead to the C?H amination product. An example of a successful sequential Dimroth triazole–indoline synthesis to the corresponding triazole-substituted indolines is presented.

METHODS OF TREATMENT OF AMYLOIDOSIS USING ASPARTYL-PROTEASE INHIBITORS

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Page/Page column 247, (2010/02/13)

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.

SUBSTITUTED UREA AND CARBAMATE, PHENACYL-2-HYDROXY-3-DIAMINOALKANE, AND BENZAMIDE-2-HYDROXY-3-DIAMINOALKANE ASPARTYL-PROTEASE INHIBITORS

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Page/Page column 281-282, (2010/02/14)

The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and condition associated with abnormal deposition of A-beta protein.

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